{"id":"bpze1-pertussis-vaccine-and-boostrix","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, erythema, swelling)"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"BPZE1 is a genetically modified live vaccine strain that replicates in the respiratory mucosa to stimulate both cellular and humoral immune responses at the site of infection. Boostrix is an acellular pertussis vaccine containing inactivated toxins and surface antigens that provides booster immunity. The combination approach aims to enhance protective immunity against pertussis through complementary mechanisms.","oneSentence":"BPZE1 is a live attenuated pertussis vaccine designed to induce mucosal and systemic immunity against Bordetella pertussis, while Boostrix is a combined acellular pertussis booster vaccine.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:57:35.728Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pertussis (whooping cough) prevention in adolescents and adults"}]},"trialDetails":[{"nctId":"NCT05116241","phase":"PHASE2","title":"Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children","status":"COMPLETED","sponsor":"ILiAD Biotechnologies","startDate":"2021-11-11","conditions":"Bordetella Pertussis, Whooping Cough","enrollment":368},{"nctId":"NCT03942406","phase":"PHASE2","title":"Study of BPZE1 Intranasal Pertussis Vaccine (Administered Via VaxINator(TM)), Prime + Boost, in Healthy Adults","status":"COMPLETED","sponsor":"ILiAD Biotechnologies","startDate":"2019-06-15","conditions":"Pertussis, Whooping Cough","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"BPZE1 pertussis vaccine and Boostrix","genericName":"BPZE1 pertussis vaccine and Boostrix","companyName":"ILiAD Biotechnologies","companyId":"iliad-biotechnologies","modality":"Biologic","firstApprovalDate":"","aiSummary":"BPZE1 is a live attenuated pertussis vaccine designed to induce mucosal and systemic immunity against Bordetella pertussis, while Boostrix is a combined acellular pertussis booster vaccine. Used for Pertussis (whooping cough) prevention in adolescents and adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}