{"id":"botulinum-type-a","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Neck pain"},{"rate":"5-10","effect":"Injection site pain or bruising"},{"rate":"5-15","effect":"Muscle weakness"},{"rate":"1-5","effect":"Ptosis (eyelid drooping)"},{"rate":"1-5","effect":"Dysphagia (difficulty swallowing)"},{"rate":"1-3","effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":{"setId":"3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74","title":"DAXXIFY (BOTULINUM TOXIN TYPE A) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [REVANCE THERAPEUTICS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A is a neurotoxin that irreversibly cleaves SNARE (soluble N-ethylmaleimide-sensitive factor attachment receptor) proteins required for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, resulting in flaccid paralysis of targeted muscles. The effect is temporary, lasting 3-4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:53.495Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"},{"name":"Spasticity"},{"name":"Cosmetic wrinkles and facial lines"}]},"trialDetails":[{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic 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