{"id":"botulinum-toxin-type-a-infiltrations","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Injection site pain or bruising"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Muscle weakness"},{"rate":"5-10","effect":"Neck pain"},{"rate":"1-5","effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle fusion and release at the presynaptic terminal. This results in flaccid paralysis of the injected muscle that typically lasts 3-4 months. The infiltration route delivers the toxin directly into target muscles for localized therapeutic effect.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:48.557Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic migraine"},{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Spasticity"},{"name":"Hyperhidrosis"},{"name":"Cosmetic wrinkles"}]},"trialDetails":[{"nctId":"NCT07034547","phase":"NA","title":"Effect of Botulinum Toxin Type A on Motor Function in Children With Cerebral Palsy","status":"RECRUITING","sponsor":"Instituto Teletón Chile","startDate":"2025-06-11","conditions":"Cerebral Palsy (CP), Spasticity Due to Cerebral Palsy, Hemiparesis","enrollment":30},{"nctId":"NCT06036043","phase":"","title":"Botulinum Toxin for Chronic Neuropathic Pain","status":"UNKNOWN","sponsor":"Region Zealand","startDate":"2023-08-01","conditions":"Neuralgia, Chronic Pain","enrollment":12},{"nctId":"NCT04595045","phase":"PHASE3","title":"Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis","status":"COMPLETED","sponsor":"Aránzazu Vázquez Doce","startDate":"2019-01-24","conditions":"Multiple Sclerosis","enrollment":84},{"nctId":"NCT05151874","phase":"","title":"Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)","status":"UNKNOWN","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2022-01","conditions":"Spasticity, Muscle, Stroke Sequelae, Movement Disorders","enrollment":12},{"nctId":"NCT04750291","phase":"PHASE4","title":"Management of Popeye Sign With Botulinum Toxin After Bicepstenotomy","status":"UNKNOWN","sponsor":"AZ Delta","startDate":"2021-08-09","conditions":"Popeye Syndrome","enrollment":20},{"nctId":"NCT03054610","phase":"PHASE1","title":"Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.","status":"COMPLETED","sponsor":"Universidad Autonoma de Nuevo Leon","startDate":"2015-01","conditions":"Plantar Fascitis, Botulinum Toxins, Type A","enrollment":60},{"nctId":"NCT02078791","phase":"PHASE4","title":"Discomfort and Psychosocial Difficulties in Fibromyalgia","status":"COMPLETED","sponsor":"University Rovira i Virgili","startDate":"2012-07","conditions":"Fibromyalgia","enrollment":66},{"nctId":"NCT01489904","phase":"PHASE2, PHASE3","title":"Application of Botulinum Toxin Type A in Salivary Glands in the Treatment of Drooling in Patients With Cerebral Palsy","status":"UNKNOWN","sponsor":"Hospital Vall d'Hebron","startDate":"2011-11","conditions":"Sialorrhea, Cerebral Palsy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Botulinum toxin type A infiltrations","genericName":"Botulinum toxin type A infiltrations","companyName":"Aránzazu Vázquez Doce","companyId":"ar-nzazu-v-zquez-doce","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin type A infiltrations are used to treat conditions such as spastic lower limb paresis associated with multiple sclerosis. The mechanism of action of botulinum toxin type A involves the hydrolysis of synaptosomal-associated protein 25 (SNAP-25), a protein involved in neurotransmitter release.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}