{"id":"botulinum-toxin-type-a-for-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Muscle weakness or paralysis (off-target)"},{"rate":null,"effect":"Ptosis (eyelid drooping)"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Neck pain"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The toxin is a zinc-dependent endopeptidase that cleaves SNAP-25 (synaptosome-associated protein of 25 kDa), preventing acetylcholine vesicles from fusing with the presynaptic membrane. This results in flaccid paralysis of injected muscles that typically lasts 3–4 months. The effect is reversible as the body gradually regenerates new SNARE proteins and neuromuscular junctions recover.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:48.663Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Spasticity"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"},{"name":"Cosmetic use (facial wrinkles)"}]},"trialDetails":[{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic 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