{"id":"botulinum-toxin-type-a-900kd","safety":{"commonSideEffects":[{"rate":"13","effect":"Headache"},{"rate":"16","effect":"Neck pain"},{"rate":"10","effect":"Injection site pain"},{"rate":"5","effect":"Muscle weakness"},{"rate":"1","effect":"Eyelid ptosis"},{"rate":"3","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The toxin is a zinc-dependent endopeptidase that cleaves SNAP-25 (synaptosome-associated protein of 25 kDa), preventing acetylcholine vesicles from fusing with the presynaptic membrane. This results in flaccid paralysis of the injected muscle that typically lasts 3-4 months. The 900 kD formulation refers to the molecular weight of the toxin-protein complex, which includes associated proteins that may influence potency and duration.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:23.878Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Severe primary axillary hyperhidrosis"},{"name":"Glabellar lines (cosmetic)"},{"name":"Crow's feet (cosmetic)"},{"name":"Forehead lines (cosmetic)"}]},"trialDetails":[{"nctId":"NCT00549783","phase":"PHASE4","title":"BOTOX® Economic Spasticity Trial (BEST)","status":"COMPLETED","sponsor":"Allergan","startDate":"2007-10","conditions":"Muscle Spasticity","enrollment":274}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["BOTOX®"],"phase":"marketed","status":"active","brandName":"Botulinum Toxin Type A 900kD","genericName":"Botulinum Toxin Type A 900kD","companyName":"Allergan","companyId":"allergan","modality":"Biologic","firstApprovalDate":"","aiSummary":"Botulinum Toxin Type A 900kD is used to treat muscle spasticity, as demonstrated in the completed clinical trial \"BOTOX Economic Spasticity Trial (BEST)\" (NCT00549783). This treatment involves administering Botulinum Toxin Type A 900kD, as opposed to a placebo, to alleviate muscle spasticity symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}