{"id":"botulinum-toxin-a-ropivaca-ne","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Numbness"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Botulinum toxin A works by cleaving the SNARE complex, preventing the release of acetylcholine from the presynaptic neuron. This results in a reduction in muscle contraction. Ropivacaine, on the other hand, works by blocking sodium channels, which prevents the initiation and transmission of nerve impulses, leading to a loss of sensation and muscle relaxation.","oneSentence":"Botulinum toxin A blocks the release of acetylcholine, a neurotransmitter that causes muscle contraction, while ropivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:46.213Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain management"},{"name":"Muscle spasticity"}]},"trialDetails":[{"nctId":"NCT01967524","phase":"PHASE3","title":"Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2013-09","conditions":"Myofascial Pelviperineal Pain","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"botulinum toxin A + ropivacaïne","genericName":"botulinum toxin A + ropivacaïne","companyName":"Nantes University Hospital","companyId":"nantes-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin A blocks the release of acetylcholine, a neurotransmitter that causes muscle contraction, while ropivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses. Used for Chronic pain management, Muscle spasticity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}