{"id":"botulinum-toxin-a-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle weakness or paralysis at injection site"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Flu-like symptoms"},{"rate":null,"effect":"Eyelid ptosis (when used periocularly)"},{"rate":null,"effect":"Antibody formation (neutralizing antibodies)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The toxin cleaves SNARE proteins required for acetylcholine vesicle release, preventing neurotransmitter transmission to muscle cells. This results in flaccid paralysis of the injected muscle that typically lasts 3–4 months. The effect is reversible as the body gradually regenerates the damaged nerve terminals.","oneSentence":"Botulinum toxin-A blocks the release of acetylcholine at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:01.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spasticity associated with cerebral palsy, stroke, or spinal cord injury"},{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Hyperhidrosis"}]},"trialDetails":[{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic 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Spasticity","enrollment":254},{"nctId":"NCT02414425","phase":"PHASE3","title":"Effect and Tolerance of Botulinum A Toxin Rectal Injections on Fecal Incontinence","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2015-11-25","conditions":"Fecal Incontinence","enrollment":200},{"nctId":"NCT02816151","phase":"PHASE3","title":"Children Toxine Botulinum Detrusor Injection in Neurogenic Vesical Hyperactivity Syndrom: Non Inferiority Multicenter Controlled Therapeutic Study Between Two Reported Weight's Doses","status":"COMPLETED","sponsor":"CHU de Reims","startDate":"2011-02","conditions":"Neurogenic Vesical Hyperactivity Syndrom","enrollment":29},{"nctId":"NCT05216250","phase":"PHASE2","title":"Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor","status":"COMPLETED","sponsor":"AbbVie","startDate":"2022-04-12","conditions":"Upper Limb Essential Tremor (UL 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Not","status":"COMPLETED","sponsor":"Bursa City Hospital","startDate":"2009-08-26","conditions":"Myofacial Pain Syndromes","enrollment":38},{"nctId":"NCT07321834","phase":"PHASE2","title":"A Study to Evaluate AI-09 In Participants With Glabellar Lines","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eirion Therapeutics Inc.","startDate":"2025-12-03","conditions":"Glabellar Lines","enrollment":68},{"nctId":"NCT04821089","phase":"PHASE1, PHASE2","title":"A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines","status":"RECRUITING","sponsor":"Ipsen","startDate":"2021-04-06","conditions":"Moderate to Severe Upper Facial Lines","enrollment":727},{"nctId":"NCT07295288","phase":"PHASE4","title":"Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis","status":"NOT_YET_RECRUITING","sponsor":"Vanderbilt University Medical 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