{"id":"botulinum-toxin-a-botox-a","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Urinary retention"},{"rate":"10-20","effect":"Urinary tract infection"},{"rate":"5-10","effect":"Incomplete bladder emptying"},{"rate":"5-10","effect":"Dysuria"},{"rate":"1-5","effect":"Muscle weakness (at injection site)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin A is a neurotoxin that irreversibly cleaves SNARE proteins (specifically SNAP-25) required for acetylcholine vesicle fusion and release at the presynaptic terminal. This prevents neuromuscular transmission, resulting in flaccid paralysis of the injected muscle. The effect is temporary, lasting 3-4 months, as the body gradually regenerates new nerve terminals.","oneSentence":"Botulinum toxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:12.246Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Overactive bladder with urge incontinence (pelvic floor disorders)"},{"name":"Muscle spasticity"},{"name":"Chronic migraine"},{"name":"Cervical dystonia"},{"name":"Blepharospasm"}]},"trialDetails":[{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT06783621","phase":"PHASE4","title":"A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products","status":"COMPLETED","sponsor":"AbbVie","startDate":"2025-01-16","conditions":"Facial Contouring","enrollment":130},{"nctId":"NCT07398755","phase":"","title":"Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure","status":"COMPLETED","sponsor":"Yuvell","startDate":"2025-09-02","conditions":"Glabellar Lines, Midface Volume Deficiency, Periorbital Wrinkling","enrollment":29},{"nctId":"NCT07018700","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine","status":"RECRUITING","sponsor":"Merz Therapeutics GmbH","startDate":"2025-08-21","conditions":"Episodic Migraine","enrollment":990},{"nctId":"NCT07018713","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine","status":"RECRUITING","sponsor":"Merz Therapeutics GmbH","startDate":"2025-08-21","conditions":"Chronic Migraine","enrollment":780},{"nctId":"NCT05308979","phase":"PHASE4","title":"Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2022-05-01","conditions":"Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome","enrollment":116},{"nctId":"NCT06047457","phase":"PHASE3","title":"A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ipsen","startDate":"2023-09-29","conditions":"Episodic Migraine","enrollment":751},{"nctId":"NCT06047444","phase":"PHASE3","title":"A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ipsen","startDate":"2023-10-12","conditions":"Chronic Migraine","enrollment":759},{"nctId":"NCT06174155","phase":"NA","title":"Comparative Study Between Botulinum Toxin-A Injection and Shock Waves on Hypertrophic Scars in Hand-burned Children","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-12-15","conditions":"Hand-burned Children","enrollment":60},{"nctId":"NCT03616067","phase":"PHASE3","title":"Evaluation of the Efficacy of the Injection of Botulinum Toxin A vs Scopolamine Patches in the Treatment of Drooling in Children With Cerebral Palsy","status":"TERMINATED","sponsor":"Hospices Civils de Lyon","startDate":"2022-04-27","conditions":"Cerebral Palsy","enrollment":23},{"nctId":"NCT07374965","phase":"","title":"A Prospective, Non-Interventional, Single-Centre Study Assessing the Efficacy of a Holistic Upper Face Treatment With Botulinum Neurotoxin A","status":"COMPLETED","sponsor":"Yuvell","startDate":"2024-01-29","conditions":"Glabellar Lines, Forehead Lines, Crow's Feet","enrollment":20},{"nctId":"NCT06585696","phase":"PHASE3","title":"A Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A for Injection (CU-20101)","status":"COMPLETED","sponsor":"Cutia Therapeutics（Wuxi）Co.,Ltd","startDate":"2024-06-11","conditions":"Glabellar Frown Lines","enrollment":554},{"nctId":"NCT07374341","phase":"NA","title":"The Effectiveness of Guided Botulinum Toxin \"A\" Injection to the Masticatory Muscles in the Management of Condylar and Subcondylar Fractures","status":"RECRUITING","sponsor":"Pakinam Gheeta","startDate":"2025-04-10","conditions":"Condylar Fractures, Subcondylar Fracture","enrollment":16},{"nctId":"NCT07360483","phase":"NA","title":"Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-01-01","conditions":"Hypertrophic Scars","enrollment":48},{"nctId":"NCT06783114","phase":"PHASE2, PHASE3","title":"A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults","status":"RECRUITING","sponsor":"Chongqing Claruvis Pharmaceutical Co., Ltd.","startDate":"2024-09-14","conditions":"Upper Limb Spasticity","enrollment":254},{"nctId":"NCT05216250","phase":"PHASE2","title":"Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor","status":"COMPLETED","sponsor":"AbbVie","startDate":"2022-04-12","conditions":"Upper Limb Essential Tremor (UL ET)","enrollment":174},{"nctId":"NCT07331844","phase":"NA","title":"BTX-A and Mirror Therapy for Chronic Stroke Spasticity","status":"COMPLETED","sponsor":"Fatih Sultan Mehmet Training and Research Hospital","startDate":"2024-05-15","conditions":"Stroke, Spastic Hemiplegia","enrollment":30},{"nctId":"NCT05534399","phase":"NA","title":"Antibiotic Strategy and Asymptomatic Bacteriuria in the Context of Intra-vesical Botulinum Toxin A Injections.","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Lille","startDate":"2026-05","conditions":"Urinary Tract Disease","enrollment":526},{"nctId":"NCT01955174","phase":"PHASE2","title":"Botulinum Toxin Injection in Hypercontractile Esophagus","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2013-08","conditions":"Nutcracker Oesophagus","enrollment":24},{"nctId":"NCT06387394","phase":"PHASE3","title":"A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2024-04-22","conditions":"Masseter Muscle Prominence","enrollment":202},{"nctId":"NCT06068855","phase":"PHASE3","title":"A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-10-17","conditions":"Masseter Muscle Prominence","enrollment":249},{"nctId":"NCT02325063","phase":"NA","title":"Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia","status":"TERMINATED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2015-12-17","conditions":"Epicondylitis, Lateral Humeral, Tennis Elbow","enrollment":13},{"nctId":"NCT03935295","phase":"PHASE4","title":"Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2020-09-03","conditions":"Adolescent Idiopathic Scoliosis","enrollment":90},{"nctId":"NCT06218251","phase":"PHASE4","title":"A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines","status":"COMPLETED","sponsor":"AbbVie","startDate":"2024-02-05","conditions":"Upper Facial Lines","enrollment":100},{"nctId":"NCT07220382","phase":"PHASE4","title":"Preoperative BOTOX® Injection for Large Ventral Hernia Repair","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2025-11-03","conditions":"Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral","enrollment":188},{"nctId":"NCT04936542","phase":"PHASE4","title":"A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.","status":"COMPLETED","sponsor":"Ipsen","startDate":"2021-06-23","conditions":"Upper Limb Spasticity","enrollment":464},{"nctId":"NCT06399718","phase":"PHASE3","title":"A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants","status":"COMPLETED","sponsor":"AbbVie","startDate":"2024-04-30","conditions":"Masseter Muscle Prominence","enrollment":207},{"nctId":"NCT06834789","phase":"PHASE1","title":"A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)","status":"COMPLETED","sponsor":"AbbVie","startDate":"2025-02-18","conditions":"Glabellar Lines","enrollment":132},{"nctId":"NCT05730556","phase":"NA","title":"A Study of Remote Electrical Neuromodulation for Acute Procedural Pain","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2023-02-13","conditions":"Chronic Migraine","enrollment":80},{"nctId":"NCT06212661","phase":"","title":"Migraine Medication Effects on Urinary Symptoms","status":"ENROLLING_BY_INVITATION","sponsor":"The Cleveland Clinic","startDate":"2024-04-05","conditions":"Overactive Bladder, Bladder Pain Syndrome, Migraine Disorders","enrollment":200},{"nctId":"NCT03187626","phase":"PHASE2, PHASE3","title":"Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-11-29","conditions":"Base-of-thumb Osteoarthritis","enrollment":60},{"nctId":"NCT06174688","phase":"PHASE3","title":"A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-12-12","conditions":"Forehead Lines","enrollment":140},{"nctId":"NCT06137287","phase":"PHASE3","title":"A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-11-22","conditions":"Masseter Muscle Prominence","enrollment":259},{"nctId":"NCT03033355","phase":"","title":"Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder","status":"COMPLETED","sponsor":"The Methodist Hospital Research Institute","startDate":"2014-02","conditions":"Multiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder","enrollment":12},{"nctId":"NCT05224349","phase":"","title":"Effectiveness and Safety of SMART [Spastic Muscle Palpation by Anatomic Landscape for BoNT-A (Botulinumtoxin-A) Injection to Reduce Muscle Tone] BoNT-A Therapy With Dysport® in Patients With Post-stroke Chronic Upper Limb Spasticity (ULS) in Real-life Setting.","status":"COMPLETED","sponsor":"Ipsen","startDate":"2022-05-09","conditions":"Post-Stroke Chronic Upper Limb Spasticity","enrollment":121},{"nctId":"NCT06514430","phase":"PHASE4","title":"Prophylactic Analgesia for Bladder Botox Injections","status":"WITHDRAWN","sponsor":"Montefiore Medical Center","startDate":"2025-07","conditions":"Urinary Incontinence, Urinary Incontinence, Urge, Overactive Bladder","enrollment":""},{"nctId":"NCT05089357","phase":"","title":"Non-interventional Study, Long Term Treatment on Glabellar Lines With Dysport® in Subjects of Chinese Origin","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2021-11-11","conditions":"Glabellar Lines","enrollment":250},{"nctId":"NCT05327972","phase":"PHASE2","title":"DEgenerative ROtator Cuff Disease and Botulinum TOXin","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-01-20","conditions":"Degenerative Rotator Cuff Disease","enrollment":60},{"nctId":"NCT07013279","phase":"PHASE3","title":"Evaluate the Efficacy and Safety of DWP712 With Moderate to Severe Glabellar Lines","status":"NOT_YET_RECRUITING","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2025-07-15","conditions":"Glabellar Lines","enrollment":324},{"nctId":"NCT07013240","phase":"PHASE3","title":"Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2025-07-05","conditions":"Sternotomy Closure,Open Heart Surgery","enrollment":50},{"nctId":"NCT04171531","phase":"PHASE3","title":"Sling vs Botox for Mixed Incontinence","status":"COMPLETED","sponsor":"NICHD Pelvic Floor Disorders Network","startDate":"2020-06-08","conditions":"Urinary Incontinence, Stress, Urinary Incontinence, Urge","enrollment":150},{"nctId":"NCT04075981","phase":"PHASE3","title":"Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-09-30","conditions":"Cardiac Surgery","enrollment":220},{"nctId":"NCT05598723","phase":"PHASE3","title":"BOTOX® vs. XEOMIN® for Chronic Migraine","status":"RECRUITING","sponsor":"Naval Medical Center Camp Lejeune","startDate":"2023-02-24","conditions":"Chronic Migraine","enrollment":128},{"nctId":"NCT05968885","phase":"PHASE4","title":"Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity","status":"RECRUITING","sponsor":"Mackay Memorial Hospital","startDate":"2021-10-01","conditions":"Urinary Bladder, Overactive, Urodynamics, Effect of Drug","enrollment":300},{"nctId":"NCT06946160","phase":"PHASE3","title":"A Non-inferiority Clinical Trial to Compare Efficacy and Safety of Abobotulinumtoxin A (Espad Pharmed) Versus AbobotulinumtoxinA (Dysport®, Ipsen Co.) for Correction of Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Espad Pharmed","startDate":"2024-05-28","conditions":"Glabellar Lines, Glabellar Frown Lines","enrollment":146},{"nctId":"NCT04073303","phase":"PHASE3","title":"BOTOX® Treatment for Adults With a Wide Lower Face Due to Masseter Muscle Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2019-08-29","conditions":"Masseter Muscle Prominence","enrollment":377},{"nctId":"NCT06941636","phase":"PHASE3","title":"Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders","status":"RECRUITING","sponsor":"Region Stockholm","startDate":"2025-05-01","conditions":"Temporomandibular Disorder","enrollment":90},{"nctId":"NCT06902805","phase":"PHASE2, PHASE3","title":"Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis.","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-05","conditions":"Base-of-thumb Osteoarthritis, Osteoarthritis","enrollment":120},{"nctId":"NCT06199336","phase":"PHASE1, PHASE2","title":"A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"JHM BioPharma (Tonghua) Co. , Ltd.","startDate":"2024-01-19","conditions":"Moderate to Severe Glabellar Lines","enrollment":190},{"nctId":"NCT06840158","phase":"PHASE3","title":"Double-blind Comparative Randomized Multicenter","status":"COMPLETED","sponsor":"Innopharm LLC","startDate":"2021-10-15","conditions":"Cerebral Palsy (CP)","enrollment":80},{"nctId":"NCT06839118","phase":"PHASE3","title":"Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache","status":"RECRUITING","sponsor":"Danish Headache Center","startDate":"2025-01-10","conditions":"Posttraumatic Headache","enrollment":80},{"nctId":"NCT06296082","phase":"PHASE2, PHASE3","title":"Comparative Study of the Effects of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity","status":"RECRUITING","sponsor":"Universiteit Antwerpen","startDate":"2024-09-01","conditions":"Stroke","enrollment":90},{"nctId":"NCT04970407","phase":"PHASE1","title":"A Comparative Study to Evaluate the Effects and Mechanism of Action of Dysport®, Botox® and Xeomin® in the Extensor Digitorum Brevis Model in Healthy Adult Male Participants","status":"COMPLETED","sponsor":"Ipsen","startDate":"2021-07-06","conditions":"Healthy Participants","enrollment":45},{"nctId":"NCT02969356","phase":"PHASE4","title":"Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC)","status":"COMPLETED","sponsor":"Ipsen","startDate":"2016-12-18","conditions":"Spastic Hemiparesis","enrollment":157},{"nctId":"NCT05769478","phase":"PHASE1","title":"Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-09-15","conditions":"Botulism, Iatrogenic Botulism","enrollment":21},{"nctId":"NCT06778421","phase":"PHASE1","title":"Impact of OnabotulinumtoxinA (BOTOX®) on Stress","status":"RECRUITING","sponsor":"Center for Advanced Facial Plastic Surgery","startDate":"2025-01-20","conditions":"Stress (Psychology), Stress, Healthy Adult Female Participants","enrollment":20},{"nctId":"NCT06499324","phase":"PHASE3","title":"Surgery with Botulinum Toxin a for Incisional Hernia","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-01-17","conditions":"Incisional Hernia","enrollment":260},{"nctId":"NCT04949399","phase":"PHASE3","title":"A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2021-07-08","conditions":"Platysma Prominence","enrollment":408},{"nctId":"NCT05698979","phase":"PHASE3","title":"Evaluation of Botulinum TOXin Type a in the Treatment of Buerger's Disease","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2025-01-01","conditions":"Buerger Disease, Raynaud Syndrome","enrollment":8},{"nctId":"NCT05647551","phase":"PHASE4","title":"A Study to Evaluate Satisfaction in Adult Participants With the Aesthetics of the Periorbital Area After JUVÉDERM® Fillers and BOTOX®/VISTABEL® Injections","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-01-05","conditions":"Facial Corrections, Facial Lines","enrollment":73},{"nctId":"NCT04819360","phase":"PHASE4","title":"Botulinum Toxin a Vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients with Multiple Sclerosis","status":"TERMINATED","sponsor":"Brigitte Schürch","startDate":"2021-06-01","conditions":"Urinary Bladder, Neurogenic, Multiple Sclerosis","enrollment":1},{"nctId":"NCT06448676","phase":"PHASE4","title":"Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides","status":"NOT_YET_RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2025-01-01","conditions":"Wrinkle","enrollment":200},{"nctId":"NCT04722809","phase":"PHASE3","title":"Efficacy of Botulinum Toxin A in the Treatment of Bruxism-related Symptomatology","status":"TERMINATED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2022-05-25","conditions":"Bruxism","enrollment":1},{"nctId":"NCT05784363","phase":"PHASE1","title":"A Study of NT 201 in the Treatment of Enlarged Pores and Excessive Sebum Production in the Face","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2022-10-27","conditions":"Enlarged Pores, Sebum Production","enrollment":31},{"nctId":"NCT04994535","phase":"PHASE3","title":"A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2021-08-10","conditions":"Platysma Prominence","enrollment":426},{"nctId":"NCT06499688","phase":"PHASE3","title":"A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Chongqing Claruvis Pharmaceutical Co., Ltd.","startDate":"2023-12-28","conditions":"Moderate to Severe Glabellar Lines","enrollment":529},{"nctId":"NCT06003049","phase":"PHASE2","title":"A Study to Evaluate Safety and Efficacy of BOTOX in Adults With Moderate COPD","status":"COMPLETED","sponsor":"RMW Testing","startDate":"2023-10-01","conditions":"COPD","enrollment":40},{"nctId":"NCT03659266","phase":"NA","title":"Effects of Combined Treatment by Botulinum Toxin and Lokomat® on Walking Ability in Chronic Stroke","status":"COMPLETED","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2019-03-07","conditions":"Stroke","enrollment":34},{"nctId":"NCT05284019","phase":"PHASE4","title":"Real World Effectiveness of Eptinezumab in Participants With Migraine","status":"TERMINATED","sponsor":"H. Lundbeck A/S","startDate":"2022-03-04","conditions":"Migraine","enrollment":32},{"nctId":"NCT06410859","phase":"PHASE2","title":"Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal Neuralgia","status":"ENROLLING_BY_INVITATION","sponsor":"LKGS_277","startDate":"2024-04-25","conditions":"Trigeminal Neuralgia","enrollment":240},{"nctId":"NCT04589364","phase":"PHASE3","title":"Study of Abobotulinum Toxin Versus Neubotulinum Toxin Injection For Hemifacial Spasm in Thai Patients","status":"NOT_YET_RECRUITING","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2024-05-01","conditions":"Hemifacial Spasm","enrollment":120},{"nctId":"NCT05485207","phase":"EARLY_PHASE1","title":"Transvaginal Botulinum Toxin A for Interstitial Cystitis / Bladder Pain Syndrome","status":"ACTIVE_NOT_RECRUITING","sponsor":"Stanford University","startDate":"2022-04-04","conditions":"Interstitial Cystitis, Bladder Pain Syndrome","enrollment":5},{"nctId":"NCT04124939","phase":"PHASE4","title":"Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2019-11-10","conditions":"Overactive Bladder","enrollment":41},{"nctId":"NCT06354127","phase":"PHASE3","title":"DWP450 for Treating Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2020-08-12","conditions":"Moderate to Severe Glabellar Lines","enrollment":473},{"nctId":"NCT00812838","phase":"PHASE2","title":"H-22411: BOTOX® for Peyronie's Disease","status":"COMPLETED","sponsor":"Mohit Khera","startDate":"2009-08-07","conditions":"Peyronie's Disease","enrollment":12},{"nctId":"NCT06212960","phase":"PHASE1","title":"Evaluate the Safety and Explore the Efficacy of DWP712 With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2023-11-28","conditions":"Glabellar Lines","enrollment":20},{"nctId":"NCT02273284","phase":"NA","title":"Pain Perception of Children and Youth Receiving Non-sedated Botulinum Toxin-A Injections Using the Buzzy®","status":"TERMINATED","sponsor":"Hamilton Health Sciences Corporation","startDate":"2014-12","conditions":"Pain","enrollment":23},{"nctId":"NCT01485601","phase":"PHASE2","title":"Safety and Efficacy Study of Botulinum Toxin Type A to Treat Glabellar Lines","status":"COMPLETED","sponsor":"Medy-Tox","startDate":"2011-12-07","conditions":"Glabellar Frown Lines","enrollment":121},{"nctId":"NCT03543254","phase":"PHASE2","title":"\"Follow the Sutures\". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2018-05-01","conditions":"Migraine Disorders, Chronic Disease","enrollment":20},{"nctId":"NCT05801146","phase":"PHASE3","title":"Evaluate the Safety and Efficacy of HG102 as Compared to Botox® in Subject With Moderate to Severe Glabellar Lines","status":"UNKNOWN","sponsor":"Hugel","startDate":"2024-01-04","conditions":"Glabellar Lines","enrollment":272},{"nctId":"NCT05980559","phase":"PHASE3","title":"Evaluation of BTX Injections in Treatment of Bruxism","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2024-01-15","conditions":"Bruxism","enrollment":12},{"nctId":"NCT05804656","phase":"PHASE3","title":"Efficacy and Safety of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines in Phase 3 Trial","status":"COMPLETED","sponsor":"CKD Bio Corporation","startDate":"2023-04-13","conditions":"Glabellar Lines","enrollment":300},{"nctId":"NCT05364580","phase":"PHASE3","title":"The Efficacy and Safety Study of Protoxin Versus Botox® in Subjects With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Protox Inc.","startDate":"2023-03-06","conditions":"Glabellar Frown Lines","enrollment":269},{"nctId":"NCT03712449","phase":"PHASE4","title":"A Study to Evaluate Participant Satisfaction With Facial Appearance Overall and the Aesthetic and Psychosocial Impact of Combined Facial Treatment","status":"COMPLETED","sponsor":"Allergan","startDate":"2019-01-22","conditions":"Facial Rhytides, Skin Folds, Loss of Volume and Skin Quality","enrollment":59},{"nctId":"NCT06034288","phase":"PHASE2","title":"Xeomin vs Botox for Treatment of Overactive Bladder Syndrome","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2023-05-04","conditions":"Overactive Bladder Syndrome","enrollment":64},{"nctId":"NCT05463965","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of QM1114-DP for the Treatment of Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2022-07-29","conditions":"Moderate to Severe Glabellar Lines","enrollment":605},{"nctId":"NCT05771623","phase":"NA","title":"Botulinum Toxin Type a Iontophoresis for Postburn Hypertrophic Scar","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-08-01","conditions":"Hypertrophic Scar","enrollment":76},{"nctId":"NCT05889026","phase":"NA","title":"The Effect of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity","status":"COMPLETED","sponsor":"Korea University Guro Hospital","startDate":"2020-08-06","conditions":"Stroke, Hemiplegia, Spastic, Muscle Spasticity","enrollment":16},{"nctId":"NCT05138835","phase":"NA","title":"BOTOX® Cosmetic and Skin Health.","status":"COMPLETED","sponsor":"Andreas Nikolis","startDate":"2021-11-11","conditions":"Oily Skin","enrollment":34},{"nctId":"NCT03915067","phase":"PHASE2","title":"BOTOX® for the Treatment of Platysma Prominence","status":"COMPLETED","sponsor":"Allergan","startDate":"2019-04-23","conditions":"Platysma Prominence","enrollment":171},{"nctId":"NCT05822323","phase":"NA","title":"Effect of Botulinum Toxin-A on Free Gingival Graft","status":"COMPLETED","sponsor":"Kevser Sokmen","startDate":"2019-10-01","conditions":"Gingival Recession, Localized","enrollment":40},{"nctId":"NCT03508869","phase":"NA","title":"Mirvaso® Gel and Dysport® for Erythema and Flushing of Rosacea","status":"TERMINATED","sponsor":"Skin Laser & Surgery Specialists","startDate":"2016-09-27","conditions":"Erythema and Flushing Associated With Rosacea","enrollment":5},{"nctId":"NCT03555916","phase":"PHASE3","title":"Botulinum Toxin Injections for Oral Neuropathic Pain","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-04-04","conditions":"Trigeminal Neuropathy, Traumatic","enrollment":43},{"nctId":"NCT00447772","phase":"PHASE3","title":"Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia","status":"COMPLETED","sponsor":"Ipsen","startDate":"2004-10","conditions":"Cervical Dystonia","enrollment":516},{"nctId":"NCT05382767","phase":"PHASE1","title":"Safety and Efficacy of CKDB-501A in Subjects With Post-stroke Upper Limb Spasticity","status":"COMPLETED","sponsor":"CKD Bio Corporation","startDate":"2022-06-02","conditions":"Post-stroke Upper Limb Spasticity","enrollment":24},{"nctId":"NCT02678377","phase":"PHASE4","title":"The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2016-02","conditions":"Mixed Urinary Incontinence, Stress Urinary Incontinence, Urgency Incontinence","enrollment":100},{"nctId":"NCT04815967","phase":"PHASE2, PHASE3","title":"Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity","status":"UNKNOWN","sponsor":"Supernus Pharmaceuticals, Inc.","startDate":"2021-11-16","conditions":"Spasticity, Cerebrovascular Accident, Multiple Sclerosis","enrollment":272},{"nctId":"NCT04099667","phase":"PHASE2, PHASE3","title":"Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity","status":"UNKNOWN","sponsor":"Supernus Pharmaceuticals, Inc.","startDate":"2019-12-17","conditions":"Spasticity","enrollment":272},{"nctId":"NCT05743634","phase":"PHASE1, PHASE2","title":"A Phase I/II Study of Recombinant Botulinum Toxin Type A for the Treatment of Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Chongqing Claruvis Pharmaceutical Co., Ltd.","startDate":"2022-03-22","conditions":"Moderate to Severe Glabellar Lines","enrollment":140},{"nctId":"NCT05623410","phase":"PHASE3","title":"Study to Compare the Efficacy and Safety of ATGC-110 (Botulinum Toxin) With Xeomin® for the Treatment of Moderate to Severe Glabellar Frown Lines","status":"UNKNOWN","sponsor":"ATGC Co., Ltd.","startDate":"2022-10-11","conditions":"Glabellar Frown Lines","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":70,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["(Botox A®)"],"phase":"phase_3","status":"active","brandName":"Botulinum toxin A (Botox A®)","genericName":"Botulinum toxin A (Botox A®)","companyName":"NICHD Pelvic Floor Disorders Network","companyId":"nichd-pelvic-floor-disorders-network","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Overactive bladder with urge incontinence (pelvic floor disorders), Muscle spasticity, Chronic migraine.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}