{"id":"botulinum-toxin-a-botox","safety":{"commonSideEffects":[{"rate":"10–20","effect":"Injection site pain, erythema, or bruising"},{"rate":"5–15","effect":"Headache"},{"rate":"1–5","effect":"Muscle weakness or paralysis (off-target)"},{"rate":"1–3","effect":"Ptosis (eyelid drooping)"},{"rate":"5–10","effect":"Antibody formation (neutralizing antibodies)"},{"rate":"1–3","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin A is a neurotoxin that irreversibly cleaves SNARE (soluble N-ethylmaleimide-sensitive factor attachment receptor) proteins required for acetylcholine vesicle release. This prevents neurotransmitter release at the neuromuscular junction, resulting in flaccid paralysis of targeted muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"Botulinum toxin A blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:45.949Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia (spasmodic torticollis)"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Hemifacial spasm"},{"name":"Primary axillary hyperhidrosis"},{"name":"Chronic migraine"},{"name":"Upper limb spasticity"},{"name":"Facial wrinkles and dynamic expression lines (cosmetic)"}]},"trialDetails":[{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic 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