{"id":"botox-vistabel","safety":{"commonSideEffects":[{"rate":"13","effect":"Headache"},{"rate":"10","effect":"Injection site pain"},{"rate":"1-3","effect":"Facial paresis"},{"rate":"1-2","effect":"Eyelid ptosis"},{"rate":"1-2","effect":"Brow ptosis"},{"rate":"2","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1201574","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle release, preventing muscle contraction. This results in temporary paralysis of injected muscles, lasting 3-4 months. The effect is reversible as the body gradually regenerates the damaged nerve terminals.","oneSentence":"BOTOX is a botulinum toxin that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:21:24.500Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe glabellar lines (frown lines)"},{"name":"Moderate to severe lateral canthal lines (crow's feet)"},{"name":"Moderate to severe forehead lines"},{"name":"Chronic migraine"},{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Hyperhidrosis (excessive sweating)"}]},"trialDetails":[{"nctId":"NCT05647551","phase":"PHASE4","title":"A Study to Evaluate Satisfaction in Adult Participants With the Aesthetics of the Periorbital Area After JUVÉDERM® Fillers and BOTOX®/VISTABEL® Injections","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-01-05","conditions":"Facial Corrections, Facial Lines","enrollment":73},{"nctId":"NCT06448676","phase":"PHASE4","title":"Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides","status":"NOT_YET_RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2025-01-01","conditions":"Wrinkle","enrollment":200},{"nctId":"NCT01608672","phase":"","title":"Long-Term Patient Satisfaction of Facial Aesthetic Treatment With BOTOX®","status":"COMPLETED","sponsor":"Allergan","startDate":"2012-04-01","conditions":"Glabellar Lines","enrollment":207},{"nctId":"NCT01271452","phase":"PHASE4","title":"Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-09","conditions":"Glabellar Lines","enrollment":224},{"nctId":"NCT01269801","phase":"PHASE4","title":"Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds","status":"COMPLETED","sponsor":"AboutSkin Dermatology and DermSurgery, PC","startDate":"2011-01","conditions":"Wrinkles","enrollment":156},{"nctId":"NCT01391312","phase":"PHASE4","title":"Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines","status":"COMPLETED","sponsor":"Allergan","startDate":"2011-06","conditions":"Glabellar Frown Lines","enrollment":40},{"nctId":"NCT00777803","phase":"PHASE3","title":"NT 201 (Xeomin®/Bocouture®) in Comparison With Clostridium Botulinum Toxin Type A in the Treatment of Glabellar Frown Lines","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2008-11","conditions":"Glabellar Frown Lines","enrollment":381}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"BOTOX®/VISTABEL®","genericName":"BOTOX®/VISTABEL®","companyName":"AbbVie","companyId":"abbvie","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BOTOX is a botulinum toxin that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis. Used for Moderate to severe glabellar lines (frown lines), Moderate to severe lateral canthal lines (crow's feet), Moderate to severe forehead lines.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}