{"id":"botox-placebo-normal-saline","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (expected from needle insertion only)"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Normal saline (0.9% sodium chloride solution) is a physiologically balanced salt solution used as a control comparator in clinical trials. It has no therapeutic mechanism of action and serves solely as a placebo to establish baseline efficacy and safety of the active investigational drug through blinded comparison.","oneSentence":"Normal saline is an inert placebo with no active pharmacological mechanism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:47.119Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Placebo control in Botox clinical trials (Phase 3)"}]},"trialDetails":[{"nctId":"NCT07426640","phase":"NA","title":"Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation","status":"COMPLETED","sponsor":"Al Mouwasat Hospital","startDate":"2021-11-01","conditions":"Premature (Early) Ejaculation","enrollment":150},{"nctId":"NCT07399860","phase":"PHASE2","title":"Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain","status":"RECRUITING","sponsor":"Lomonosov Moscow State University Medical Research and Educational Center","startDate":"2026-02-01","conditions":"Hemorrhoids, Postoperative Pain","enrollment":292},{"nctId":"NCT05478551","phase":"PHASE2, PHASE3","title":"Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-01","conditions":"Scar, Hypertrophic Scar","enrollment":12},{"nctId":"NCT06237465","phase":"PHASE4","title":"Botulinum Toxin-A for Hidradenitis Suppurativa","status":"WITHDRAWN","sponsor":"Yale University","startDate":"2025-01","conditions":"Hidradenitis Suppurativa, Hidradenitis Suppurativa \\(HS\\), Hidradenitis Suppurativa, Acne Inversa","enrollment":""},{"nctId":"NCT07270042","phase":"NA","title":"Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection","status":"NOT_YET_RECRUITING","sponsor":"Tishreen University","startDate":"2025-12-01","conditions":"Hyperactive Masseter Muscle","enrollment":20},{"nctId":"NCT07220382","phase":"PHASE4","title":"Preoperative BOTOX® Injection for Large Ventral Hernia Repair","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2025-11-03","conditions":"Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral","enrollment":188},{"nctId":"NCT05330078","phase":"EARLY_PHASE1","title":"Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2022-03-11","conditions":"Keloid","enrollment":10},{"nctId":"NCT05466539","phase":"PHASE4","title":"Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A","status":"COMPLETED","sponsor":"Emory University","startDate":"2024-04-25","conditions":"Compartment Syndrome of Leg","enrollment":3},{"nctId":"NCT07070817","phase":"NA","title":"A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar Palsy","status":"ENROLLING_BY_INVITATION","sponsor":"houyajing","startDate":"2024-06-01","conditions":"Sialorrhea True Bulbar Palsy Medullary Injury","enrollment":70},{"nctId":"NCT05327972","phase":"PHASE2","title":"DEgenerative ROtator Cuff Disease and Botulinum TOXin","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-01-20","conditions":"Degenerative Rotator Cuff Disease","enrollment":60},{"nctId":"NCT03887377","phase":"PHASE2, PHASE3","title":"The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2019-06-10","conditions":"Scar, Hypertrophic Scar, Mammary Disorder","enrollment":22},{"nctId":"NCT07013240","phase":"PHASE3","title":"Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2025-07-05","conditions":"Sternotomy Closure,Open Heart Surgery","enrollment":50},{"nctId":"NCT04075981","phase":"PHASE3","title":"Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-09-30","conditions":"Cardiac Surgery","enrollment":220},{"nctId":"NCT04073303","phase":"PHASE3","title":"BOTOX® Treatment for Adults With a Wide Lower Face Due to Masseter Muscle Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2019-08-29","conditions":"Masseter Muscle Prominence","enrollment":377},{"nctId":"NCT06902805","phase":"PHASE2, PHASE3","title":"Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis.","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-05","conditions":"Base-of-thumb Osteoarthritis, Osteoarthritis","enrollment":120},{"nctId":"NCT04857671","phase":"PHASE3","title":"Botulinum Toxin A in Frequent and Chronic Tension-type Headache","status":"COMPLETED","sponsor":"Helse Nord-Trøndelag HF","startDate":"2022-10-03","conditions":"Tension-Type Headache","enrollment":66},{"nctId":"NCT06814535","phase":"PHASE2, PHASE3","title":"A Comparative Study on the Impact of Trigger Points Injection of Platelet Rich Plasma Versus Botulinum Toxin on the Relief of Jaw Muscles Myofascial Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-06-01","conditions":"Patients with Jaw Muscles Myofascial Pain","enrollment":60},{"nctId":"NCT04270526","phase":"PHASE4","title":"Minimizing Pain During Office Intradetrussor Botox Injection","status":"COMPLETED","sponsor":"Boston Urogynecology Associates","startDate":"2020-08-15","conditions":"Overactive Bladder, Overactive Detrusor, Overactive Bladder Syndrome","enrollment":85},{"nctId":"NCT06839118","phase":"PHASE3","title":"Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache","status":"RECRUITING","sponsor":"Danish Headache Center","startDate":"2025-01-10","conditions":"Posttraumatic Headache","enrollment":80},{"nctId":"NCT06778421","phase":"PHASE1","title":"Impact of OnabotulinumtoxinA (BOTOX®) on Stress","status":"RECRUITING","sponsor":"Center for Advanced Facial Plastic Surgery","startDate":"2025-01-20","conditions":"Stress (Psychology), Stress, Healthy Adult Female Participants","enrollment":20},{"nctId":"NCT06793683","phase":"EARLY_PHASE1","title":"Early BOTOX After Spinal Cord Injury","status":"ENROLLING_BY_INVITATION","sponsor":"University of Washington","startDate":"2024-07-27","conditions":"Spinal Cord Injuries","enrollment":10},{"nctId":"NCT06499324","phase":"PHASE3","title":"Surgery with Botulinum Toxin a for Incisional Hernia","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-01-17","conditions":"Incisional Hernia","enrollment":260},{"nctId":"NCT02196155","phase":"NA","title":"Botulinum Toxin A Versus Steroids for the Treatment of Chronic Plantar Fasciitis","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2016-07","conditions":"Plantar Fasciitis","enrollment":54},{"nctId":"NCT04949399","phase":"PHASE3","title":"A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2021-07-08","conditions":"Platysma Prominence","enrollment":408},{"nctId":"NCT06676475","phase":"PHASE2, PHASE3","title":"Comparison Between Botox and Magnesium Sulfate Effect in Treatment of Myofascial Pain Trigger Points Within the Masseter Muscle","status":"NOT_YET_RECRUITING","sponsor":"Misr University for Science and Technology","startDate":"2024-12-01","conditions":"Myofacial Pain, Trigger Points, Myofascial","enrollment":60},{"nctId":"NCT05964257","phase":"PHASE3","title":"To Evaluate the Efficacy and Safety of LIZTOX in Subjects with Benign Masseteric Hypertrophy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Huons Biopharma","startDate":"2023-07-25","conditions":"Benign Masseteric Hypertrophy","enrollment":188},{"nctId":"NCT04845178","phase":"PHASE2","title":"Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults","status":"COMPLETED","sponsor":"AEON Biopharma, Inc.","startDate":"2021-03-01","conditions":"Migraine","enrollment":797},{"nctId":"NCT01177358","phase":"PHASE2","title":"Botox in the Healing of Surgical Wounds of the Neck","status":"COMPLETED","sponsor":"Nova Scotia Health Authority","startDate":"2010-05-31","conditions":"Scar","enrollment":40},{"nctId":"NCT04994535","phase":"PHASE3","title":"A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence","status":"COMPLETED","sponsor":"AbbVie","startDate":"2021-08-10","conditions":"Platysma Prominence","enrollment":426},{"nctId":"NCT06530524","phase":"PHASE2","title":"Pretreatment Botulinum Toxin in Head and Neck Cancer Surgery","status":"NOT_YET_RECRUITING","sponsor":"Sir Mortimer B. Davis - Jewish General Hospital","startDate":"2024-10-01","conditions":"Head Neck Cancer, Xerostomia Following Radiotherapy","enrollment":50},{"nctId":"NCT06003049","phase":"PHASE2","title":"A Study to Evaluate Safety and Efficacy of BOTOX in Adults With Moderate COPD","status":"COMPLETED","sponsor":"RMW Testing","startDate":"2023-10-01","conditions":"COPD","enrollment":40},{"nctId":"NCT06460194","phase":"PHASE2","title":"Treatment of Frostbite Sequelae With Botulinum Toxin A","status":"WITHDRAWN","sponsor":"University Hospital of North Norway","startDate":"2022-11","conditions":"Cold Hypersensitivity, Vascular System Injuries, Vibration; Disorder","enrollment":""},{"nctId":"NCT06315790","phase":"PHASE3","title":"Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia","status":"RECRUITING","sponsor":"Henrik Schytz","startDate":"2023-11-01","conditions":"Trigeminal Neuralgia","enrollment":80},{"nctId":"NCT04849988","phase":"PHASE2","title":"A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia","status":"COMPLETED","sponsor":"AEON Biopharma, Inc.","startDate":"2021-03-29","conditions":"Cervical Dystonia","enrollment":61},{"nctId":"NCT06250543","phase":"PHASE4","title":"Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder","status":"COMPLETED","sponsor":"Niko Kavcic","startDate":"2018-08-14","conditions":"Overactive Bladder","enrollment":64},{"nctId":"NCT04383912","phase":"NA","title":"Onabotulinum Toxin A in Direct Brow Lift","status":"UNKNOWN","sponsor":"Nova Scotia Health Authority","startDate":"2020-11-18","conditions":"Direct Brow Lift, Scarring","enrollment":16},{"nctId":"NCT06094309","phase":"NA","title":"Effectiveness of Botulinum Toxin in Freezing of Gate in Parkinson's Disease Walking in Parkinson's Disease.","status":"UNKNOWN","sponsor":"Centro Hospitalar de Lisboa Central","startDate":"2024-06-01","conditions":"Freezing of Gate, Parkinson Disease, Botulinum Toxin","enrollment":20},{"nctId":"NCT04922983","phase":"PHASE2","title":"Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis","status":"UNKNOWN","sponsor":"Manhattan Physical Medicine and Rehabilitation, LLP","startDate":"2021-07-01","conditions":"Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis; Lumbar Region","enrollment":42},{"nctId":"NCT03055767","phase":"PHASE2","title":"Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2017-03-01","conditions":"Migraine Disorders, Headache, Migraine, Pediatrics","enrollment":17},{"nctId":"NCT03821402","phase":"PHASE2","title":"Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity","status":"COMPLETED","sponsor":"Revance Therapeutics, Inc.","startDate":"2018-12-12","conditions":"Upper Limb Spasticity","enrollment":83},{"nctId":"NCT04695600","phase":"PHASE2, PHASE3","title":"Onabotulinum Toxin A (Botox) in the Treatment of Transfer Dysphagia","status":"UNKNOWN","sponsor":"All India Institute of Medical Sciences","startDate":"2023-08-22","conditions":"Transfer Dysphagia, Oropharyngeal Dysphagia, Cricopharyngeus Muscle Dysfunction","enrollment":100},{"nctId":"NCT02088632","phase":"PHASE2","title":"Incobotulinum Toxin for the Treatment of Trigeminal Neuralgia","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2014-03-14","conditions":"Trigeminal Neuralgia","enrollment":6},{"nctId":"NCT05863286","phase":"NA","title":"Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-12-30","conditions":"Dislocation of Temporomandibular Joint TMJ, Subluxation of Temporomandibular Joint","enrollment":28},{"nctId":"NCT05765071","phase":"NA","title":"Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections.","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2023-06-01","conditions":"Chronic Exertional Compartment Syndrome","enrollment":50},{"nctId":"NCT05604729","phase":"NA","title":"The Effect on Envelope of Motion in Asymptomatic Bruxers","status":"UNKNOWN","sponsor":"Region Västerbotten","startDate":"2023-09-01","conditions":"Tooth Wear, Bruxism","enrollment":60},{"nctId":"NCT03555916","phase":"PHASE3","title":"Botulinum Toxin Injections for Oral Neuropathic Pain","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-04-04","conditions":"Trigeminal Neuropathy, Traumatic","enrollment":43},{"nctId":"NCT05217355","phase":"PHASE2","title":"A Phase II Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Medytox Korea","startDate":"2021-12-28","conditions":"Glabellar Frown Lines","enrollment":50},{"nctId":"NCT03223298","phase":"PHASE3","title":"Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2018-08-31","conditions":"Pain, Head, Pain Syndrome, Temporomandibular Disorder","enrollment":75},{"nctId":"NCT03608397","phase":"PHASE3","title":"Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)","status":"COMPLETED","sponsor":"Revance Therapeutics, Inc.","startDate":"2018-06-20","conditions":"Cervical Dystonia","enrollment":301},{"nctId":"NCT04294251","phase":"PHASE3","title":"Efficacy and Safety of DWP450 in Subjects With Benign Masseteric Hypertrophy","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2020-03-04","conditions":"Benign Masseteric Hypertrophy","enrollment":180},{"nctId":"NCT05620316","phase":"NA","title":"The Use of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle to Treat Sleep Bruxism","status":"COMPLETED","sponsor":"Damascus University","startDate":"2021-03-15","conditions":"Nocturnal Bruxism","enrollment":22},{"nctId":"NCT02035397","phase":"PHASE2","title":"Intragastric Injections of Botox for the Treatment of Obesity","status":"UNKNOWN","sponsor":"Norwegian University of Science and Technology","startDate":"2014-02","conditions":"Obesity, Morbid","enrollment":20},{"nctId":"NCT04917731","phase":"PHASE1","title":"Botulinum Toxin Type A for Cold Intolerance Secondary to Digital Amputations and Replantations: A Pilot Study","status":"UNKNOWN","sponsor":"Massachusetts General Hospital","startDate":"2021-06-02","conditions":"Cold Intolerance","enrollment":28},{"nctId":"NCT05411900","phase":"PHASE2","title":"BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome","status":"UNKNOWN","sponsor":"Francesco Bono","startDate":"2022-05-25","conditions":"Carpal Tunnel Syndrome, Neurogenic Inflammation, Pain","enrollment":164},{"nctId":"NCT05382832","phase":"NA","title":"Botox Vs Spinal Cord Stimulation in the Treatment of Refractory Migraine Clinical Trial","status":"UNKNOWN","sponsor":"EPC Education s.r.o.","startDate":"2022-08-01","conditions":"Migraine","enrollment":50},{"nctId":"NCT04277247","phase":"PHASE2, PHASE3","title":"Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2021-01-12","conditions":"Dystonia Disorder, Parkinson Disease","enrollment":40},{"nctId":"NCT02173405","phase":"PHASE1","title":"Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2014-08-01","conditions":"Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Trigger Point Pain, Myofascial","enrollment":10},{"nctId":"NCT02051933","phase":"NA","title":"The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2013-01","conditions":"Equinus Contracture","enrollment":10},{"nctId":"NCT05275647","phase":"PHASE2","title":"Efficacy and Safety of Low Energy Shock Wave Plus BotulinumToxin A in Treating Patients With Interstitial Cystitis","status":"UNKNOWN","sponsor":"Buddhist Tzu Chi General Hospital","startDate":"2021-05-18","conditions":"Interstitial Cystitis","enrollment":75},{"nctId":"NCT03717961","phase":"PHASE3","title":"Efficacy of Botulinum Toxin A in Adult Subjects With Raynaud Phenomenon Secondary to Systemic Sclerosis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-10-15","conditions":"Raynaud Phenomenon Secondary to Systemic Sclerosis","enrollment":91},{"nctId":"NCT04443244","phase":"PHASE2","title":"Evaluate the Safety and Efficacy of Botulax® in Subjects With Benign Masseteric Hypertrophy","status":"COMPLETED","sponsor":"Hugel","startDate":"2020-05-27","conditions":"Benign Masseteric Hypertrophy","enrollment":80},{"nctId":"NCT04585620","phase":"PHASE1, PHASE2","title":"Botulinum Toxin A as Treatment for Chronic Postsurgical Pain Following Lung Cancer Surgery","status":"UNKNOWN","sponsor":"Allan Vestergaard Danielsen, MD","startDate":"2022-09-01","conditions":"Chronic Pain, Post-thoracotomy Pain Syndrome, Pain, Neuropathic","enrollment":30},{"nctId":"NCT04750291","phase":"PHASE4","title":"Management of Popeye Sign With Botulinum Toxin After Bicepstenotomy","status":"UNKNOWN","sponsor":"AZ Delta","startDate":"2021-08-09","conditions":"Popeye Syndrome","enrollment":20},{"nctId":"NCT04807920","phase":"PHASE4","title":"BOTOX® at the Time of Prolapse Surgery for OAB","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2021-09-23","conditions":"Urinary Bladder, Overactive, Pelvic Organ Prolapse","enrollment":138},{"nctId":"NCT01589263","phase":"PHASE2","title":"Effectiveness of onaBoNT-A vs Oral Tamsulosin in Men With BPH and LUTS","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2012-06-01","conditions":"Benign Prostatic Hyperplasia, Lower Urinary Track Symptoms","enrollment":63},{"nctId":"NCT04470401","phase":"PHASE4","title":"The Treatment of Shoulder Pain in Hemiplegic Spastic Patients With Botulinum Toxin A","status":"COMPLETED","sponsor":"Faculdade de Ciências Médicas da Santa Casa de São Paulo","startDate":"2019-06-05","conditions":"Shoulder Pain","enrollment":24},{"nctId":"NCT03639766","phase":"PHASE4","title":"The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's Phenomenon","status":"TERMINATED","sponsor":"University of Central Florida","startDate":"2018-08-31","conditions":"Raynaud Phenomenon","enrollment":3},{"nctId":"NCT00527202","phase":"PHASE4","title":"Efficacy Study of Botox to Treat Neuropathic Pain","status":"COMPLETED","sponsor":"Hospital Ambroise Paré Paris","startDate":"2004-06","conditions":"Postherpetic Neuralgia, Nerve Trauma","enrollment":29},{"nctId":"NCT03861936","phase":"PHASE2","title":"BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence","status":"COMPLETED","sponsor":"Allergan","startDate":"2019-05-16","conditions":"Masseter Muscle Prominence","enrollment":150},{"nctId":"NCT04143815","phase":"PHASE2","title":"Clinical Trial to Evaluate the Efficacy and Safety of MBA-P01 in Treatment of Glabellar Lines","status":"COMPLETED","sponsor":"Medy-Tox","startDate":"2019-05-20","conditions":"Glabellar Frown Lines","enrollment":200},{"nctId":"NCT04143854","phase":"PHASE2","title":"Clinical Trial to Evaluate the Efficacy and Safety of MBA-P01 in Treatment of Lateral Canthal Lines","status":"COMPLETED","sponsor":"Medy-Tox","startDate":"2019-05-21","conditions":"Lateral Canthal Lines","enrollment":150},{"nctId":"NCT04439825","phase":"PHASE1","title":"Impact of Botox Treatment Into the Upper One Third of the Face an Area on Mood and Self -Appearance Satisfaction","status":"COMPLETED","sponsor":"DeNova Research","startDate":"2020-07-20","conditions":"Mood","enrollment":45},{"nctId":"NCT04794504","phase":"PHASE2","title":"Investigating Temporalis and Masseter Botox Injection Before Orthognathic Surgery to Improve Postoperative Pain","status":"NOT_YET_RECRUITING","sponsor":"Kingsway Oral & Maxillofacial Surgery","startDate":"2021-04-19","conditions":"Pain, Postoperative","enrollment":64},{"nctId":"NCT03663101","phase":"PHASE2","title":"Dysport in Post-Surgical Neuralgia","status":"COMPLETED","sponsor":"Ipsen","startDate":"2018-10-30","conditions":"Chronic Scar Pain","enrollment":16},{"nctId":"NCT00711087","phase":"PHASE2","title":"Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)","status":"TERMINATED","sponsor":"Baylor College of Medicine","startDate":"2007-07","conditions":"Neurogenic Bladder Dysfunction Nos, Spinal Cord Injury","enrollment":1},{"nctId":"NCT01225341","phase":"NA","title":"Botulinum Toxin A for Herpes Labialis","status":"TERMINATED","sponsor":"DeNova Research","startDate":"2010-08","conditions":"Herpes Labialis","enrollment":20},{"nctId":"NCT02623829","phase":"PHASE2","title":"Botulinum Toxin is a Potential Prophylactic Therapy for Minimizing Post-excisional Scarring (Allergan Botox Scar Study)","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2015-12-01","conditions":"Post-operative Excessive Scarring","enrollment":42},{"nctId":"NCT00661089","phase":"NA","title":"Randomized DB Controlled Trial of Botulinum Toxin A in Hemiplegic Shoulder Pain and Spasticity","status":"COMPLETED","sponsor":"Shirley Ryan AbilityLab","startDate":"2003-09","conditions":"Post-stroke Shoulder Pain and Spasticity","enrollment":21},{"nctId":"NCT00320281","phase":"PHASE4","title":"Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.","status":"COMPLETED","sponsor":"Craig Hospital","startDate":"2006-04","conditions":"Spinal Cord Injury, Pain","enrollment":19},{"nctId":"NCT03301272","phase":"PHASE2","title":"Effectiveness of Botox on Reducing Rest Tremor in Parkinson's Disease","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2018-03-22","conditions":"Parkinson Disease","enrollment":16},{"nctId":"NCT01553201","phase":"PHASE1, PHASE2","title":"Botulinum Toxin for Pelvic Pain in Women With Endometriosis","status":"COMPLETED","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2014-07-30","conditions":"Endometriosis, Chronic Pelvic Pain, Pelvic Muscle Spasm","enrollment":30},{"nctId":"NCT03452345","phase":"PHASE3","title":"MEDITOXIN® Treatment in Subject With Benign Masseteric Hypertrophy","status":"COMPLETED","sponsor":"Medy-Tox","startDate":"2018-04-09","conditions":"Masseter Muscle Hypertrophy","enrollment":180},{"nctId":"NCT03760198","phase":"PHASE3","title":"Evaluate the Efficacy and Safety of MEDITOXIN in Treatment of Primary Axillary Hyperhidrosis","status":"COMPLETED","sponsor":"Medy-Tox","startDate":"2018-08-03","conditions":"Hyperhidrosis Primary Focal Axilla","enrollment":220},{"nctId":"NCT02160288","phase":"PHASE2","title":"Effects of Botox in Obstructed Defecation Syndrome","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2016-02","conditions":"Obstructed Defecation Syndrome (ODS)","enrollment":1},{"nctId":"NCT03102762","phase":"PHASE2, PHASE3","title":"Botulinum Toxin for Erectile Dysfunction","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-01-03","conditions":"Sexual Dysfunction, Erectile Dysfunction","enrollment":70},{"nctId":"NCT03052764","phase":"PHASE4","title":"Evaluation of an Alternative Injection Paradigm for OnabotulinumtoxinA (BOTOX®) in the Treatment of Overactive Bladder in Patients With Urinary Incontinence","status":"COMPLETED","sponsor":"Allergan","startDate":"2016-12-12","conditions":"Urinary Bladder, Overactive, Urinary Incontinence","enrollment":120},{"nctId":"NCT01591746","phase":"PHASE3","title":"Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2012-08","conditions":"Breast Cancer, Pain, Postoperative, BRCA1 Mutation","enrollment":131},{"nctId":"NCT01350375","phase":"PHASE2, PHASE3","title":"Safety and Efficacy Study of Botox in the Treatment of Forward Head Posture With Associated Episodic Headache Disorder","status":"COMPLETED","sponsor":"The Research Center of Southern California","startDate":"2009-09","conditions":"Forward Head Posture With Associated Episodic Headache Disorder","enrollment":30},{"nctId":"NCT04057755","phase":"PHASE3","title":"Botulinum Toxin A as a Treatment for Provoked Vestibulodynia","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2016-05-15","conditions":"Vulvodynia","enrollment":90},{"nctId":"NCT02773641","phase":"PHASE3","title":"Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2016-05","conditions":"Vulvodynia","enrollment":90},{"nctId":"NCT01422161","phase":"PHASE3","title":"Study of Botulinum Toxin and Recovery of Hand Function After Stroke","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2010-04","conditions":"Stroke With Hemiparesis","enrollment":16},{"nctId":"NCT01821573","phase":"PHASE3","title":"Study of the Effect of Botulinum Toxin Injection in Rectus Femoris and Triceps on the Length and the Strength During Locomotion in Chronic Hemiparetic Patients","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-07","conditions":"COMPARISON BETWEEN GROUP TREATED WITH BOTULINUM TOXIN AND PLACEBO","enrollment":36},{"nctId":"NCT02010775","phase":"PHASE2","title":"Botulinum Toxin Type A (BOTOX®) Treatment of Masseter Muscle Hypertrophy","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-01-20","conditions":"Masseter Muscle Hypertrophy","enrollment":187},{"nctId":"NCT01189747","phase":"PHASE3","title":"Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-10-01","conditions":"Lateral Canthus Rhytides, Crow's Feet Lines","enrollment":446},{"nctId":"NCT01107392","phase":"PHASE2","title":"Safety and Efficacy of Botulinum Toxin Type A to Treat Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-08-01","conditions":"Benign Prostatic Hyperplasia","enrollment":315},{"nctId":"NCT01600716","phase":"PHASE3","title":"Safety and Efficacy Study of OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Neurogenic Detrusor Overactivity (NDO) in Non-Catheterizing Patients With Multiple Sclerosis (MS)","status":"COMPLETED","sponsor":"Allergan","startDate":"2012-06-13","conditions":"Urinary Incontinence, Multiple Sclerosis, Neurogenic Bladder","enrollment":144},{"nctId":"NCT03508882","phase":"PHASE4","title":"Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2015-07-01","conditions":"Blepharospasm, Hemifacial Spasm, Botulinum Toxins, Type A","enrollment":100},{"nctId":"NCT03928496","phase":"PHASE4","title":"Abobotulinumtoxina Efficacy in Post-Traumatic Headache","status":"COMPLETED","sponsor":"VA Greater Los Angeles Healthcare System","startDate":"2013-08-01","conditions":"Post-Traumatic Headache","enrollment":40},{"nctId":"NCT01767519","phase":"PHASE3","title":"A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence","status":"COMPLETED","sponsor":"Allergan","startDate":"2013-03-01","conditions":"Overactive Bladder, Urinary Incontinence","enrollment":356},{"nctId":"NCT01777620","phase":"PHASE4","title":"A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides","status":"COMPLETED","sponsor":"Allergan","startDate":"2013-01-31","conditions":"Facial Rhytides","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Botox placebo (normal saline)","genericName":"Botox placebo (normal saline)","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botox placebo, also known as preservative-free saline, has been used in clinical trials to study its effects on various conditions, including glabellar rhytides, chronic migraine, and neurogenic bladder dysfunction. The mechanism of action of Botox placebo is unknown, as indicated by ChEMBL.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}