{"id":"botox-onabotulinumtoxina","safety":{"commonSideEffects":[{"rate":"7–15%","effect":"Headache"},{"rate":"5–10%","effect":"Neck pain"},{"rate":"5–10%","effect":"Injection site pain"},{"rate":"5–15%","effect":"Muscle weakness"},{"rate":"1–5%","effect":"Eyelid ptosis"},{"rate":"1–3%","effect":"Dry mouth"},{"rate":"1–3%","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, leading to flaccid paralysis of injected muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:35.251Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Hyperhidrosis"},{"name":"Glabellar lines and facial wrinkles (cosmetic)"}]},"trialDetails":[{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain 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