{"id":"botox-inj","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Neck pain"},{"rate":"1-5","effect":"Injection site pain"},{"rate":"1-5","effect":"Muscle weakness"},{"rate":"1-3","effect":"Eyelid ptosis"},{"rate":"1-3","effect":"Dry mouth"},{"rate":"1-3","effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL1201574","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle fusion and release at motor nerve terminals. This results in temporary flaccid paralysis of injected muscles, lasting 3-4 months before neuromuscular junction recovery. The effect is localized to the injection site and reversible.","oneSentence":"Botox (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:30.555Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Hyperhidrosis"},{"name":"Glabellar lines and facial wrinkles (cosmetic)"}]},"trialDetails":[{"nctId":"NCT07360483","phase":"NA","title":"Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-01-01","conditions":"Hypertrophic Scars","enrollment":48},{"nctId":"NCT06356025","phase":"PHASE4","title":"Botulinum Toxin Injection in the UES for R-CPD","status":"ACTIVE_NOT_RECRUITING","sponsor":"AZ Delta","startDate":"2024-09-02","conditions":"Retrograde Cricopharyngeus Dysfunction","enrollment":50},{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT07013279","phase":"PHASE3","title":"Evaluate the Efficacy and Safety of DWP712 With Moderate to Severe Glabellar Lines","status":"NOT_YET_RECRUITING","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2025-07-15","conditions":"Glabellar Lines","enrollment":324},{"nctId":"NCT05590520","phase":"NA","title":"Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure","status":"UNKNOWN","sponsor":"Pak Emirates Military Hospital","startDate":"2022-11-01","conditions":"Fissure in Ano","enrollment":90},{"nctId":"NCT05415865","phase":"PHASE3","title":"The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder","status":"UNKNOWN","sponsor":"Herlev and Gentofte Hospital","startDate":"2022-09-12","conditions":"Urge Incontinence, Overactive Bladder, Anesthesia, Local","enrollment":50},{"nctId":"NCT01791920","phase":"PHASE3","title":"To Evaluate the Safety and Efficacy of Botulax® Are Not Inferior to Those of Botox® in the Treatment of Glabellar Lines","status":"COMPLETED","sponsor":"Hugel","startDate":"2011-08","conditions":"Skin Aging","enrollment":262},{"nctId":"NCT04830345","phase":"PHASE3","title":"Efficacy and Safety of Botulinum Toxin at Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"EuBiologics Co.,Ltd","startDate":"2020-06-29","conditions":"Glabellar Frown Lines","enrollment":290},{"nctId":"NCT04821882","phase":"NA","title":"Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis","status":"COMPLETED","sponsor":"National Defense Medical Center, Taiwan","startDate":"2019-05-01","conditions":"Bladder Pain Syndrome, Interstitial Cystitis","enrollment":29},{"nctId":"NCT04281745","phase":"PHASE4","title":"Long-term Open-label Treatment of Moderate to Severe Glabellar Lines With CORETOX®","status":"UNKNOWN","sponsor":"Medy-Tox","startDate":"2019-10-17","conditions":"Glabellar Frown Lines","enrollment":200},{"nctId":"NCT04081402","phase":"PHASE3","title":"A Phase 1/3 Clinical Trial to Evaluate the Safety and Efficacy of HUTOX Compared to Botox® in Subjects With Moderate to Severe Crow's Feet Lines","status":"UNKNOWN","sponsor":"Huons Co., Ltd.","startDate":"2018-11-01","conditions":"Crow's Feet Lines","enrollment":290},{"nctId":"NCT02961673","phase":"PHASE1, PHASE2","title":"The Safety and Efficacy Study of HU-014 Versus Botox® in Subject With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Huons Co., Ltd.","startDate":"2016-09","conditions":"Glabellar Lines","enrollment":57},{"nctId":"NCT03440671","phase":"PHASE3","title":"The Safety and Efficacy Study of Hutox Versus Botox® in Subject With Moderate to Severe Glabellar Lines","status":"UNKNOWN","sponsor":"Huons Co., Ltd.","startDate":"2017-11-30","conditions":"Glabellar Frown Lines","enrollment":260},{"nctId":"NCT01791881","phase":"PHASE3","title":"Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of \"Hugeltox Inj.\" in Essential Blepharospasm","status":"COMPLETED","sponsor":"Hugel","startDate":"2008-04","conditions":"Essential Blepharospasm","enrollment":172}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Botox Inj","genericName":"Botox Inj","companyName":"Huons Co., Ltd.","companyId":"huons-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"Botox (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}