{"id":"botox-cosmetic","safety":{"commonSideEffects":[{"rate":"7–13%","effect":"Headache"},{"rate":"1–5%","effect":"Injection site pain or bruising"},{"rate":"1–3%","effect":"Eyelid ptosis"},{"rate":"1–2%","effect":"Brow ptosis"},{"rate":"1–2%","effect":"Facial weakness or asymmetry"}]},"_chembl":null,"_dailymed":{"setId":"485d9b71-6881-42c5-a620-a4360c7192ab","title":"BOTOX COSMETIC (ONABOTULINUMTOXINA) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [ALLERGAN, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A binds to SNARE proteins on presynaptic nerve terminals and cleaves SNAP-25, preventing acetylcholine vesicle release. This temporary paralysis of facial muscles smooths dynamic wrinkles caused by repetitive muscle contractions, particularly on the forehead, between the brows, and around the eyes. Effects typically appear within 3–7 days and peak at 2 weeks, lasting approximately 3–4 months.","oneSentence":"Botox Cosmetic blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing the appearance of wrinkles.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:45.928Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Temporary improvement of moderate to severe glabellar lines (frown lines between the brows)"},{"name":"Temporary improvement of forehead lines"},{"name":"Temporary improvement of crow's feet (lateral canthal lines)"}]},"trialDetails":[{"nctId":"NCT07291661","phase":"NA","title":"The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-01-01","conditions":"Refractory Constipation, Fecal Incontinence in Children","enrollment":54},{"nctId":"NCT06212661","phase":"","title":"Migraine Medication Effects on Urinary Symptoms","status":"ENROLLING_BY_INVITATION","sponsor":"The Cleveland Clinic","startDate":"2024-04-05","conditions":"Overactive Bladder, Bladder Pain Syndrome, Migraine Disorders","enrollment":200},{"nctId":"NCT03874780","phase":"NA","title":"Vibe First In Human Study for the Assessment of Safety and Initial Performance of the Vibe Delivery System in Subjects With Idiopathic Overactive Bladder","status":"COMPLETED","sponsor":"Vensica Therapeutics Ltd.","startDate":"2019-01-29","conditions":"Overactive Bladder","enrollment":10},{"nctId":"NCT00529386","phase":"PHASE1","title":"Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)","status":"TERMINATED","sponsor":"Queen's University","startDate":"2006-01","conditions":"Prostatitis, Chronic Pain Syndrome","enrollment":7},{"nctId":"NCT00250952","phase":"NA","title":"Study to Determine If the Volume Used to Dilute BOTOX Cosmetic™ for Injection Affects Its Overall Effect and Duration.","status":"COMPLETED","sponsor":"Carruthers Dermatology Centre","startDate":"2005-02","conditions":"Skin Wrinkling","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":43,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Botox Cosmetic™","genericName":"Botox Cosmetic™","companyName":"Carruthers Dermatology Centre","companyId":"carruthers-dermatology-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botox Cosmetic blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing the appearance of wrinkles. Used for Temporary improvement of moderate to severe glabellar lines (frown lines between the brows), Temporary improvement of forehead lines, Temporary improvement of crow's feet (lateral canthal lines).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}