{"id":"botox-200-unt-injection","safety":{"commonSideEffects":[{"rate":"10–15","effect":"Headache"},{"rate":"5–10","effect":"Injection site pain or bruising"},{"rate":"1–5","effect":"Muscle weakness (off-target)"},{"rate":"1–3","effect":"Ptosis (eyelid drooping)"},{"rate":"1–3","effect":"Antibody formation (neutralizing)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botox cleaves SNARE proteins required for acetylcholine vesicle fusion and release at motor nerve terminals. This results in flaccid paralysis of injected muscles, lasting 3–4 months before neuromuscular junction recovery. The effect is used therapeutically to reduce muscle hyperactivity and cosmetically to reduce dynamic wrinkles.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:32.032Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Chronic migraine"},{"name":"Spasticity"},{"name":"Cosmetic wrinkle reduction"},{"name":"Hyperhidrosis"}]},"trialDetails":[{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT06839118","phase":"PHASE3","title":"Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache","status":"RECRUITING","sponsor":"Danish Headache Center","startDate":"2025-01-10","conditions":"Posttraumatic Headache","enrollment":80},{"nctId":"NCT04580238","phase":"PHASE1","title":"Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache","status":"WITHDRAWN","sponsor":"University of Alberta","startDate":"2023-12","conditions":"Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A","enrollment":""},{"nctId":"NCT06485453","phase":"","title":"Predictive Urodynamic Parameters for The Treatment Efficacy of Onabotulinum A Toxin in Neurogenic Lower Urinary Tract Dysfunction","status":"COMPLETED","sponsor":"University of Gaziantep","startDate":"2013-09-01","conditions":"Neurogenic Bladder Disorder","enrollment":74},{"nctId":"NCT03991299","phase":"PHASE1, PHASE2","title":"Investigating Effects of BOTOX on Weight Loss and Glucose Tolerance in Obese, Type 2 Diabetic Subjects","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-04-29","conditions":"Obese, Diabetes Mellitus, Type 2","enrollment":4},{"nctId":"NCT03758235","phase":"PHASE3","title":"Overactive Bladder Syndrome: Incobotulinumtoxin Versus Onabotulinumtoxin","status":"UNKNOWN","sponsor":"University Of Perugia","startDate":"2018-09-01","conditions":"Overactive Bladder Syndrome","enrollment":140},{"nctId":"NCT03063827","phase":"","title":"Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients","status":"COMPLETED","sponsor":"Buddhist Tzu Chi General Hospital","startDate":"2010-01","conditions":"Neurogenic Bladder","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Botox","Botulinumtoxin-A","onabotulinum toxin a"],"phase":"phase_3","status":"active","brandName":"Botox 200 UNT Injection","genericName":"Botox 200 UNT Injection","companyName":"University of Gaziantep","companyId":"university-of-gaziantep","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botox 200 UNT Injection is used to treat Overactive Bladder Syndrome, according to ClinicalTrials.gov. The mechanism of action of Botox is unknown, as stated by ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}