{"id":"botox-200-unit-s","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Neck pain"},{"rate":"5-10","effect":"Muscle weakness"},{"rate":"1-5","effect":"Injection site pain"},{"rate":"1-3","effect":"Flu-like symptoms"},{"rate":"1-5","effect":"Eyelid ptosis"},{"rate":"1-3","effect":"Diplopia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle fusion and release at the presynaptic terminal. This results in flaccid paralysis of the injected muscle that typically lasts 3-4 months. The effect is reversible as the body gradually regenerates the cleaved proteins and forms new neuromuscular junctions.","oneSentence":"BOTOX (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:38.966Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Spasticity"},{"name":"Cosmetic wrinkle reduction"}]},"trialDetails":[{"nctId":"NCT02555982","phase":"PHASE3","title":"Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2016-06-27","conditions":"Essential Head Tremor","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BOTOX ® 200 Unités","genericName":"BOTOX ® 200 Unités","companyName":"University Hospital, Clermont-Ferrand","companyId":"university-hospital-clermont-ferrand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BOTOX (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}