{"id":"botox-100-unt-injection","safety":{"commonSideEffects":[{"rate":"5–15%","effect":"Headache"},{"rate":"10–20%","effect":"Injection site pain or bruising"},{"rate":"1–5%","effect":"Muscle weakness or paralysis (off-target)"},{"rate":"1–3%","effect":"Ptosis (eyelid drooping)"},{"rate":"1–2%","effect":"Diplopia (double vision)"},{"rate":"5–10%","effect":"Neck pain"},{"rate":"1–3%","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A binds to and cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release at the neuromuscular junction. This prevents muscle contraction in the injected area, producing a temporary paralytic effect that lasts 3–4 months. The effect is reversible as the body gradually regenerates new SNARE complexes.","oneSentence":"Botox blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:45.932Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"},{"name":"Glabellar lines and facial wrinkles (cosmetic)"},{"name":"Spasticity"}]},"trialDetails":[{"nctId":"NCT05308979","phase":"PHASE4","title":"Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2022-05-01","conditions":"Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome","enrollment":116},{"nctId":"NCT06216886","phase":"PHASE4","title":"OnabotulinumtoxinA for Trigeminal Neuralgia","status":"RECRUITING","sponsor":"Stanford University","startDate":"2024-06-01","conditions":"Trigeminal Neuralgia","enrollment":20},{"nctId":"NCT05806164","phase":"PHASE4","title":"Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence","status":"RECRUITING","sponsor":"Women and Infants Hospital of Rhode Island","startDate":"2023-06-06","conditions":"Urgency Urinary Incontinence","enrollment":432},{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT04819360","phase":"PHASE4","title":"Botulinum Toxin a Vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients with Multiple Sclerosis","status":"TERMINATED","sponsor":"Brigitte Schürch","startDate":"2021-06-01","conditions":"Urinary Bladder, Neurogenic, Multiple Sclerosis","enrollment":1},{"nctId":"NCT06250543","phase":"PHASE4","title":"Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder","status":"COMPLETED","sponsor":"Niko Kavcic","startDate":"2018-08-14","conditions":"Overactive Bladder","enrollment":64},{"nctId":"NCT06034288","phase":"PHASE2","title":"Xeomin vs Botox for Treatment of Overactive Bladder Syndrome","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2023-05-04","conditions":"Overactive Bladder Syndrome","enrollment":64},{"nctId":"NCT05340439","phase":"PHASE2","title":"INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT)","status":"UNKNOWN","sponsor":"Universita di Verona","startDate":"2022-06","conditions":"Spastic Cerebral Palsy","enrollment":30},{"nctId":"NCT04807920","phase":"PHASE4","title":"BOTOX® at the Time of Prolapse Surgery for OAB","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2021-09-23","conditions":"Urinary Bladder, Overactive, Pelvic Organ Prolapse","enrollment":138},{"nctId":"NCT04794504","phase":"PHASE2","title":"Investigating Temporalis and Masseter Botox Injection Before Orthognathic Surgery to Improve Postoperative Pain","status":"NOT_YET_RECRUITING","sponsor":"Kingsway Oral & Maxillofacial Surgery","startDate":"2021-04-19","conditions":"Pain, Postoperative","enrollment":64},{"nctId":"NCT03758235","phase":"PHASE3","title":"Overactive Bladder Syndrome: Incobotulinumtoxin Versus Onabotulinumtoxin","status":"UNKNOWN","sponsor":"University Of Perugia","startDate":"2018-09-01","conditions":"Overactive Bladder Syndrome","enrollment":140},{"nctId":"NCT04305743","phase":"PHASE4","title":"Post-procedural Pain Associated With 5 Versus 20 Intravesical Injections of Onabotulinumtoxin A","status":"RECRUITING","sponsor":"University of South Florida","startDate":"2019-10-09","conditions":"Urinary Bladder, Overactive, Incontinence, Urge, Incontinence, Urinary","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Botox","OnabotulinumtoxinA","onabotulinumtoxinA"],"phase":"marketed","status":"active","brandName":"Botox 100 UNT Injection","genericName":"Botox 100 UNT Injection","companyName":"Brigitte Schürch","companyId":"brigitte-sch-rch","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botox blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}