{"id":"borneol","rwe":[{"pmid":"41912014","year":"2026","title":"Borneol-caprylic acid deep eutectic solvent (DES) based microemulsion gel for improved topical delivery of ivermectin.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"},{"pmid":"41878450","year":"2026","title":"A curcumin-borneol prodrug delays rheumatoid arthritis progression by inhibiting the activation of the MAPK/AP-1-MMP9 inflammatory axis.","finding":"","journal":"Frontiers in immunology","studyType":"Clinical Study"},{"pmid":"41833847","year":"2026","title":"Enhancing effect and safety assessment of borneol on the oral absorption of sub-100 nm PLGA nanoparticles.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"},{"pmid":"41829166","year":"2026","title":"Rosemary Essential Oil as a Natural Additive in Food Industry: Recent Developments in Encapsulation Techniques.","finding":"","journal":"Foods (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41814753","year":"2026","title":"[Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment].","finding":"","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","studyType":"Clinical Study"}],"tags":[{"label":"Non-Standardized Chemical Allergen [EPC]","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Active","category":"status"},{"label":"irritation","category":"indication"},{"label":"abrasion","category":"indication"},{"label":"pain","category":"indication"},{"label":"soreness","category":"indication"},{"label":"burning","category":"indication"},{"label":"itching","category":"indication"},{"label":"WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd.","category":"company"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd.","patents":[],"pricing":[],"allNames":"hemorrhoid, fissure, proctalgiasuppositories","offLabel":[],"synonyms":["Hemorrhoid, Fissure, ProctalgiaSuppositories","ACTIVATED CHARCOAL"],"timeline":[],"approvals":[],"brandName":"Hemorrhoid, Fissure, ProctalgiaSuppositories","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Non-Standardized Chemical Allergen [EPC]","explanation":"Imagine your anal tissue is like a sensitive skin that gets irritated easily. Proctalgia Suppositories helps to calm down this sensitive skin, reducing the feelings of pain, burning, and itching. This is done by interacting with the tissue at a molecular level, but the exact details of how it works are not yet fully understood.","oneSentence":"Proctalgia Suppositories works by interacting with the anal tissue to reduce symptoms of irritation, pain, and discomfort.","technicalDetail":"As a non-standardized chemical allergen, Proctalgia Suppositories likely works by binding to specific receptors on the anal tissue, triggering a response that reduces inflammation and discomfort. However, the exact molecular mechanisms involved are not well characterized, and further research is needed to fully understand its effects."},"commercial":{},"references":[{"id":1,"url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:\"BORNEOL\"","fields":["mechanism","indications","adverse_reactions","contraindications","warnings","dosage"],"source":"OpenFDA Label"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=borneol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=borneol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-31T10:31:51.247278","biosimilars":[],"competitors":[],"genericName":"borneol","indications":{"approved":[{"name":"irritation","source":"OpenFDA Label","regulator":"FDA"},{"name":"abrasion","source":"OpenFDA Label","regulator":"FDA"},{"name":"pain","source":"OpenFDA Label","regulator":"FDA"},{"name":"soreness","source":"OpenFDA Label","regulator":"FDA"},{"name":"burning","source":"OpenFDA Label","regulator":"FDA"},{"name":"itching","source":"OpenFDA Label","regulator":"FDA"},{"name":"discomfort","source":"OpenFDA Label","regulator":"FDA"},{"name":"hemorrhoids","source":"OpenFDA Label","regulator":"FDA"},{"name":"inflammation","source":"OpenFDA Label","regulator":"FDA"},{"name":"anorectal irritation","source":"OpenFDA Label","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07340411","phase":"PHASE2","title":"Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis","status":"RECRUITING","sponsor":"Taichung Veterans General Hospital","startDate":"2023-07-05","conditions":["Chronic Rhinosinusitis","Postoperative Care"],"enrollment":80,"completionDate":"2026-03-31"},{"nctId":"NCT06664671","phase":"NA","title":"The Effect of Thyme Oil in Asthmatic Patients","status":"COMPLETED","sponsor":"Inonu University","startDate":"2024-11-01","conditions":["Asthma","Asthma Patients"],"enrollment":156,"completionDate":"2025-05-20"},{"nctId":"NCT06927336","phase":"PHASE4","title":"The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury","status":"NOT_YET_RECRUITING","sponsor":"The Second Affiliated Hospital of Kunming Medical University","startDate":"2025-04-25","conditions":["tDCS","Cerebellum","Brain Injury","Disturbance of Consciousness"],"enrollment":200,"completionDate":"2026-12-30"},{"nctId":"NCT06911437","phase":"","title":"Clinical Study on the Combination of Xiaoyu Zhitong Formula and Lymphatic Drainage Technique to Improve the Symptoms of Knee Pain and Swelling in Cold Dampness Obstruction Type","status":"ENROLLING_BY_INVITATION","sponsor":"tang jie","startDate":"2024-10-10","conditions":["Knee Osteoarthritis (OA)"],"enrollment":100,"completionDate":"2026-03-31"},{"nctId":"NCT06583369","phase":"NA","title":"The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs","status":"RECRUITING","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2024-03-25","conditions":["Hand-Foot Syndrome"],"enrollment":220,"completionDate":"2025-03-25"},{"nctId":"NCT06156449","phase":"NA","title":"Effect of Thyme Oil on Respiratory Symptoms and Hemodynamic Parameters in COPD Patients","status":"UNKNOWN","sponsor":"Inonu University","startDate":"2023-11-15","conditions":["Patient Engagement"],"enrollment":120,"completionDate":"2024-04-15"},{"nctId":"NCT05901532","phase":"PHASE2","title":"Nasal Irrigation With Chinese Herbal Medicine as an Adjunctive Treatment in Allergic Rhinitis","status":"COMPLETED","sponsor":"Taichung Veterans General Hospital","startDate":"2020-11-01","conditions":["Rhinitis, Allergic","Nasal Lavage","Medicine, Chinese Traditional"],"enrollment":38,"completionDate":"2023-02-28"},{"nctId":"NCT04950920","phase":"PHASE3","title":"Phase III Clinical Trial of Y-2 Sublingual Tablets in the Treatment of Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Peking University Third Hospital","startDate":"2021-06-28","conditions":["Stroke"],"enrollment":914,"completionDate":"2022-11-14"},{"nctId":"NCT03495206","phase":"PHASE1","title":"Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet","status":"UNKNOWN","sponsor":"Yantai YenePharma Co., Ltd.","startDate":"2018-10-25","conditions":["Stroke, Acute","Intracranial Hemorrhages"],"enrollment":24,"completionDate":"2021-02"},{"nctId":"NCT02029118","phase":"EARLY_PHASE1","title":"Acupoint Application in Patients With Stable Angina Pectoris (AASAP)","status":"COMPLETED","sponsor":"Chengdu University of Traditional Chinese Medicine","startDate":"2012-10","conditions":["Stable Angina Pectoris"],"enrollment":200,"completionDate":"2015-08"},{"nctId":"NCT02430350","phase":"PHASE3","title":"Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Jiangsu Simcere Pharmaceutical Co., Ltd.","startDate":"2015-05","conditions":["Acute Ischemic Stroke"],"enrollment":1200,"completionDate":"2016-12"},{"nctId":"NCT01891097","phase":"NA","title":"Combined Electroacupuncture and Auricular Acupuncture for Persistent Insomnia","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2012-07","conditions":["Insomnia"],"enrollment":224,"completionDate":"2015-05"},{"nctId":"NCT01929096","phase":"PHASE2","title":"Compound Edaravone Injection for Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Jiangsu Simcere Pharmaceutical Co., Ltd.","startDate":"2013-08","conditions":["Acute Ischemic Stroke"],"enrollment":400,"completionDate":"2015-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical"},"crossReferences":{"UNII":"2P3VWU3H10","SPL_ID":"486510a7-f140-3a89-e063-6294a90a7bf7"},"formularyStatus":[],"_enricherVersion":"v2-openfda","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd.","relationship":"Original Developer"}],"publicationCount":1464,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"originalDeveloper":"WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd.","recentPublications":[{"date":"2026 Mar 28","pmid":"41912014","title":"Borneol-caprylic acid deep eutectic solvent (DES) based microemulsion gel for improved topical delivery of ivermectin.","journal":"International journal of pharmaceutics"},{"date":"2026","pmid":"41878450","title":"A curcumin-borneol prodrug delays rheumatoid arthritis progression by inhibiting the activation of the MAPK/AP-1-MMP9 inflammatory axis.","journal":"Frontiers in immunology"},{"date":"2026 Mar 13","pmid":"41833847","title":"Enhancing effect and safety assessment of borneol on the oral absorption of sub-100 nm PLGA nanoparticles.","journal":"International journal of pharmaceutics"},{"date":"2026 Mar 5","pmid":"41829166","title":"Rosemary Essential Oil as a Natural Additive in Food Industry: Recent Developments in Encapsulation Techniques.","journal":"Foods (Basel, Switzerland)"},{"date":"2026 Jan","pmid":"41814753","title":"[Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment].","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd.","companyId":"wu-xi-zhong-zhi-wei-na-technology-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Proctalgia Suppositories (borneol) is a non-standardized chemical allergen used to treat various anal symptoms such as irritation, abrasion, pain, soreness, burning, itching, discomfort, and hemorrhoids. The exact target of Proctalgia Suppositories is unknown, but it is believed to work by interacting with the anal tissue. As it is a small molecule, its exact mechanism of action is not well understood. Proctalgia Suppositories is currently owned by WU XI ZHONG ZHI WEI NA TECHNOLOGY CO., Ltd. and its commercial status is unclear.","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}