{"id":"boric-acid-vaginal-suppository","safety":{"commonSideEffects":["Vaginal burning or irritation","Watery vaginal discharge","Redness"],"contraindications":["Pregnancy","Open wounds or abrasions in vaginal area","Hypersensitivity to boric acid"]},"_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"explanation":"Boric acid acts as a weak acid that lowers vaginal pH, creating conditions unfavorable for pathogenic organisms including Candida species and bacteria associated with bacterial vaginosis. The acidic environment helps restore normal vaginal flora balance.","oneSentence":"Creates an acidic vaginal environment that inhibits growth of pathogenic fungi and bacteria while supporting normal vaginal flora."},"_scrapedAt":"2026-03-28T06:33:23.323Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123196,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Fluconazole","brand":"Diflucan","company":"Pfizer","rationale":"Oral antifungal for vulvovaginal candidiasis"},{"name":"Clotrimazole","brand":"Gyne-Lotrimin","company":null,"rationale":"Topical azole antifungal for vaginal yeast infections"},{"name":"Metronidazole vaginal gel","brand":"MetroGel-Vaginal","company":null,"rationale":"First-line treatment for bacterial vaginosis"}],"description":"Boric acid vaginal suppository is an antiseptic and antifungal agent used intravaginally for the treatment of recurrent vulvovaginal candidiasis and bacterial vaginosis. It works by creating an acidic environment that inhibits the growth of pathogenic organisms while supporting normal vaginal flora.","indications":{"approved":[{"status":"approved","condition":"Recurrent vulvovaginal candidiasis","patientPopulation":"Adult women, typically after failure of conventional antifungal therapy"},{"status":"approved","condition":"Bacterial vaginosis","patientPopulation":"Adult women"}]},"trialDetails":[{"nctId":"NCT06516757","phase":"NA","title":"A Single Group Study to Evaluate the Effects of a Boric Acid Suppository on Vaginal Health.","status":"COMPLETED","sponsor":"Love Wellness","startDate":"2024-04-05","conditions":"Vaginal Health, Bacterial Vaginosis","enrollment":40},{"nctId":"NCT04208555","phase":"NA","title":"Comparison of Boric Acid vs. Terconazole in Treatment of RVVC","status":"UNKNOWN","sponsor":"Hatem AbuHashim","startDate":"2020-01-15","conditions":"Vulvovaginal Candidiasis","enrollment":76},{"nctId":"NCT00353561","phase":"PHASE3","title":"Diabetes Mellitus and Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Indian Council of Medical Research","startDate":"2004-06","conditions":"Diabetes Mellitus, Vulvovaginal Candidiasis","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"Boric Acid Vaginal Suppository","genericName":"Boric Acid Vaginal Suppository","companyName":"Hatem AbuHashim","companyId":"hatem-abuhashim","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}