{"id":"borage-seed-oil","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"},{"rate":"null","effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2108130","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of borage seed oil is not fully understood, but it is thought to work by reducing inflammation and improving the body's response to injury. This may be due to the presence of GLA, which is converted into prostaglandins that have anti-inflammatory effects. Additionally, borage seed oil may also have antioxidant properties, which can help protect cells from damage.","oneSentence":"Borage seed oil is used to provide essential fatty acids, particularly gamma-linolenic acid (GLA), which may help reduce inflammation and improve symptoms of conditions such as eczema and rheumatoid arthritis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:29.872Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Eczema"},{"name":"Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT05873933","phase":"NA","title":"An Investigation of a Multi-Function Skincare Product to Improve Aging, Eczema, and Acne Outcomes","status":"WITHDRAWN","sponsor":"Hemptress","startDate":"2024-07-01","conditions":"Acne, Eczema, Skin Aging","enrollment":""},{"nctId":"NCT02350595","phase":"NA","title":"A Study on the Possible Health Effects of Lean Fish and Fatty Fish Intake in Overweight or Obese Adults","status":"COMPLETED","sponsor":"University of Bergen","startDate":"2011-08","conditions":"Overweight, Obesity","enrollment":76},{"nctId":"NCT03265327","phase":"NA","title":"Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms","status":"COMPLETED","sponsor":"Nature's Way Canada","startDate":"2017-08-16","conditions":"Dry Eye","enrollment":63},{"nctId":"NCT03862872","phase":"NA","title":"Effects of Bend Beauty's Anti-Aging Formula on Inflammatory Markers","status":"WITHDRAWN","sponsor":"Bend Beauty Inc.","startDate":"2020-02","conditions":"Inflammation, Skin Abnormalities, Skin Pigment","enrollment":""},{"nctId":"NCT03141931","phase":"NA","title":"The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye","status":"COMPLETED","sponsor":"The University of New South Wales","startDate":"2017-08-21","conditions":"Dry Eye","enrollment":119},{"nctId":"NCT03842514","phase":"NA","title":"Food Additives - Do Processed Diets Impact on Gut and Metabolic Health","status":"COMPLETED","sponsor":"University of Aberdeen","startDate":"2019-05-01","conditions":"Gut Health, Metabolic Health","enrollment":20},{"nctId":"NCT01145066","phase":"PHASE2","title":"Botanical Oil Supplementation in Diabetic and Metabolic Syndrome Subjects","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2009-05","conditions":"Diabetes, Metabolic Syndrome x","enrollment":80},{"nctId":"NCT02337231","phase":"NA","title":"Botanical Oils Study to Determine Genetic Differences in the Way Your Body Processes Fats in Edible Oils","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2014-06-24","conditions":"Genetic Differences of Lipid Metabolism/Healthy Subjects","enrollment":66},{"nctId":"NCT03569930","phase":"PHASE4","title":"Irritation and Anal Bleeding in Patients Affected by Hemorrhoids.","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2018-05-01","conditions":"Hemorrhoids","enrollment":105},{"nctId":"NCT02130908","phase":"NA","title":"A Study on the Possible Health Effects of Lean Fish, Fatty Fish and Lean Meat Intake in Non-obese Adults","status":"COMPLETED","sponsor":"University of Bergen","startDate":"2011-03","conditions":"Metabolic Disorders, Obesity","enrollment":45},{"nctId":"NCT01560988","phase":"PHASE3","title":"Borage and Echium Seed Oils for Asthma","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2013-02","conditions":"Asthma","enrollment":62},{"nctId":"NCT00806442","phase":"PHASE1, PHASE2","title":"Treatment of Bronchial Asthma With Borage and Echium Seed Oils","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2008-12","conditions":"Bronchial Asthma","enrollment":43},{"nctId":"NCT01768429","phase":"NA","title":"The Effect of n-3 Fatty Acids and Fish on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Metabolism","status":"COMPLETED","sponsor":"University of Eastern Finland","startDate":"2012-10","conditions":"Hyperglycemia","enrollment":79},{"nctId":"NCT01211769","phase":"PHASE3","title":"Effects of Omegas 3 and 6 on Alcohol Dependence","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2006-02","conditions":"Alcohol Dependence","enrollment":80},{"nctId":"NCT00072982","phase":"PHASE3","title":"Treatment of Rheumatoid Arthritis With Marine and Botanical Oils","status":"UNKNOWN","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2006-11","conditions":"Rheumatoid Arthritis","enrollment":156},{"nctId":"NCT00029679","phase":"PHASE1, PHASE2","title":"Borage Oil and Ginkgo Biloba (EGb 761) in Asthma","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2000-09","conditions":"Asthma","enrollment":280}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":32,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GLA"],"phase":"phase_3","status":"active","brandName":"borage seed oil","genericName":"borage seed oil","companyName":"National Center for Complementary and Integrative Health (NCCIH)","companyId":"national-center-for-complementary-and-integrative-health-nccih","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Borage seed oil is used to provide essential fatty acids, particularly gamma-linolenic acid (GLA), which may help reduce inflammation and improve symptoms of conditions such as eczema and rheumatoid arthritis. Used for Eczema, Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}