{"id":"borage-and-echium-seed-oils","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These plant-derived oils are rich in gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA), which are converted to anti-inflammatory mediators that suppress pro-inflammatory cytokine production and reduce immune cell activation. The fatty acids compete with arachidonic acid metabolism, shifting the balance toward resolution of inflammation and potentially benefiting autoimmune and inflammatory conditions.","oneSentence":"Borage and Echium seed oils provide omega-3 and omega-6 polyunsaturated fatty acids that modulate inflammatory pathways and immune responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:19.984Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT01560988","phase":"PHASE3","title":"Borage and Echium Seed Oils for Asthma","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2013-02","conditions":"Asthma","enrollment":62},{"nctId":"NCT00806442","phase":"PHASE1, PHASE2","title":"Treatment of Bronchial Asthma With Borage and Echium Seed Oils","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2008-12","conditions":"Bronchial Asthma","enrollment":43}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Borage and Echium Seed Oils","genericName":"Borage and Echium Seed Oils","companyName":"Brigham and Women's Hospital","companyId":"brigham-and-women-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Borage and Echium seed oils provide omega-3 and omega-6 polyunsaturated fatty acids that modulate inflammatory pathways and immune responses. Used for Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}