{"id":"bont-a-intra-prostatic-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Urinary tract infection"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Hematuria"},{"rate":null,"effect":"Dysuria"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BONT-A (botulinum neurotoxin type A) inhibits acetylcholine release by cleaving SNARE proteins at the neuromuscular junction. When injected intra-prostatically, it reduces detrusor and prostatic smooth muscle contractions, decreasing urinary frequency, urgency, and improving flow in benign prostatic hyperplasia and lower urinary tract symptoms.","oneSentence":"Botulinum toxin type A injected directly into the prostate blocks acetylcholine release at nerve endings to reduce smooth muscle contractions and lower urinary symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:15.158Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lower urinary tract symptoms secondary to benign prostatic hyperplasia"},{"name":"Overactive bladder symptoms"}]},"trialDetails":[{"nctId":"NCT01275521","phase":"PHASE3","title":"A-botulinic Toxin for Symptomatic Benign Prostate Hypertrophy","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2011-01-10","conditions":"Prostatic Hyperplasia","enrollment":127}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BONT-A intra-prostatic injection","genericName":"BONT-A intra-prostatic injection","companyName":"University Hospital, Bordeaux","companyId":"university-hospital-bordeaux","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BONT-A intra-prostatic injection is being studied as a treatment for Prostatic Hyperplasia. It is being investigated as part of an optimized medical treatment for Benign Prostatic Hyperplasia (BPH) through a clinical trial.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}