{"id":"bone-substitute-i-factortm","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at surgical site"},{"rate":null,"effect":"Delayed bone healing"},{"rate":null,"effect":"Inflammatory response"}]},"_chembl":{"chemblId":"CHEMBL6068575","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"i-Factor is a resorbable bone graft substitute composed of a collagen matrix combined with recombinant human bone morphogenetic protein (rhBMP) or similar osteoinductive factors. It acts as both a structural scaffold for bone ingrowth and a delivery vehicle for growth factors that recruit and differentiate osteoprogenitor cells into osteoblasts, facilitating natural bone healing and regeneration in orthopedic applications.","oneSentence":"i-Factor is a bone substitute that promotes bone regeneration by providing a scaffold and delivering osteoinductive signals to stimulate new bone formation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:06.211Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone defect repair and regeneration in orthopedic surgery"},{"name":"Spinal fusion procedures"},{"name":"Maxillofacial and dental bone reconstruction"}]},"trialDetails":[{"nctId":"NCT03112122","phase":"PHASE4","title":"Study for the Treatment of the Bone Marrow Edema:Core Decompression VS Bone Marrow Concentrate (BMC) VS Bone Substitute","status":"TERMINATED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2016-03-11","conditions":"Bone Marrow Edema","enrollment":1}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"bone substitute i-FactorTM","genericName":"bone substitute i-FactorTM","companyName":"Istituto Ortopedico Rizzoli","companyId":"istituto-ortopedico-rizzoli","modality":"Biologic","firstApprovalDate":"","aiSummary":"i-Factor is a bone substitute that promotes bone regeneration by providing a scaffold and delivering osteoinductive signals to stimulate new bone formation. Used for Bone defect repair and regeneration in orthopedic surgery, Spinal fusion procedures, Maxillofacial and dental bone reconstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}