{"id":"bolus-without-paracetamol","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL5592090","moleculeType":null,"molecularWeight":"152.15"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This allows for rapid absorption and increased bioavailability of the medication, which can be particularly beneficial for drugs that are poorly absorbed orally or have a narrow therapeutic index.","oneSentence":"Bolus injections deliver a concentrated dose of medication directly into the bloodstream, bypassing the digestive system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:27.877Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of acute conditions such as severe allergic reactions, anaphylaxis, and acute pain management"}]},"trialDetails":[{"nctId":"NCT06780111","phase":"PHASE1, PHASE2","title":"Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-07-30","conditions":"Esophageal Squamous Cell Carcinoma","enrollment":298},{"nctId":"NCT07268911","phase":"NA","title":"Femoral Rami Obturator Nerve Trunk (FRONT) Block in Intramedullary Nail Surgery .","status":"RECRUITING","sponsor":"South Valley University","startDate":"2025-11-01","conditions":"Anterior Hip Analgesia","enrollment":60},{"nctId":"NCT07231926","phase":"NA","title":"Intrathecal Morphine for Recovery and Outcomes After VATS","status":"RECRUITING","sponsor":"Ataturk University","startDate":"2025-12-01","conditions":"Postoperative Pain Management in Video-Assisted Thoracoscopic Surgery","enrollment":52},{"nctId":"NCT06298227","phase":"NA","title":"Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy","status":"RECRUITING","sponsor":"Istanbul Medipol University Hospital","startDate":"2024-03-11","conditions":"Kidney Diseases, Kidney Failure","enrollment":60},{"nctId":"NCT06653465","phase":"PHASE2, PHASE3","title":"Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-06","conditions":"Delirium in Old Age","enrollment":1930},{"nctId":"NCT05345639","phase":"PHASE3","title":"Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2022-08-01","conditions":"Pain, Postoperative, Cardiac Surgery","enrollment":254},{"nctId":"NCT06463899","phase":"NA","title":"Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time","status":"RECRUITING","sponsor":"CHU de Reims","startDate":"2023-02-08","conditions":"Duration of Hospitalization in Intensive Care Unit","enrollment":114},{"nctId":"NCT05158270","phase":"NA","title":"Erector Spinae Plane Block Versus Subcostal Anterior Quadratus Lumborum Block in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2021-11-15","conditions":"Laparoscopic Cholecystectomy, Quadratus Lumborum Block, Erector Spinae Plane Block","enrollment":81},{"nctId":"NCT05621161","phase":"NA","title":"ESPB vs FICB for Pain Management Following Total Hip Prosthesis Surgery","status":"COMPLETED","sponsor":"Mursel Ekinci","startDate":"2022-11-28","conditions":"Knee Osteoarthritis, Knee Disease, Knee Arthritis","enrollment":60},{"nctId":"NCT03921970","phase":"NA","title":"Ultrasound-Guided Erector Spinae Plane Block Following Laparoscopic Sleeve Gastrectomy Surgery","status":"WITHDRAWN","sponsor":"Medipol University","startDate":"2019-06-01","conditions":"Obesity","enrollment":""},{"nctId":"NCT04189289","phase":"NA","title":"Laparoscopic Bariatric Surgery and Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Antalya Training and Research Hospital","startDate":"2019-12-03","conditions":"Obesity, Postoperative Pain, Bariatric Surgery","enrollment":54},{"nctId":"NCT01540838","phase":"PHASE4","title":"Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis","status":"COMPLETED","sponsor":"University of Helsinki","startDate":"2012-02","conditions":"Bacterial Meningitis","enrollment":375},{"nctId":"NCT03967314","phase":"NA","title":"An mTLIP Block for Analgesia Management After Lumbar Spinal Surgery.","status":"COMPLETED","sponsor":"Medipol University","startDate":"2019-01-01","conditions":"Lumbar Disc Herniation","enrollment":60},{"nctId":"NCT02285010","phase":"PHASE4","title":"Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2014-11","conditions":"Post Operative Pain","enrollment":125},{"nctId":"NCT01077752","phase":"PHASE3","title":"Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-02","conditions":"Pain, Postoperative","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":135,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Paracetamol=acetaminophen"],"phase":"marketed","status":"active","brandName":"Bolus without paracetamol","genericName":"Bolus without paracetamol","companyName":"University of Helsinki","companyId":"university-of-helsinki","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bolus is a type of continuous preperitoneal infusion of local anesthetics, such as ropivacaine, used to manage pain, particularly postoperative pain. It has also been studied for its potential benefits in conditions like obesity and postoperative pain following bariatric surgery and laparoscopic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}