{"id":"bnx-sublingual-film","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Buprenorphine is a partial mu-opioid receptor agonist that produces analgesia and reduces cravings in opioid use disorder. The sublingual film formulation allows rapid absorption through the oral mucosa, providing faster onset compared to tablets. As a partial agonist, it has a lower abuse potential and ceiling effect on respiratory depression compared to full opioid agonists.","oneSentence":"BNX is a buprenorphine sublingual film that binds to opioid receptors to provide analgesia and opioid dependence treatment.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:43:57.568Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder maintenance treatment"},{"name":"Moderate to severe pain"}]},"trialDetails":[{"nctId":"NCT01908842","phase":"PHASE3","title":"Efficacy of BNX Sublingual Tablets Versus BNX Sublingual Film for Treatment of Opioid-Dependent Adults","status":"COMPLETED","sponsor":"Orexo AB","startDate":"2013-08","conditions":"Opioid Dependence, on Agonist Therapy","enrollment":759}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Suboxone film"],"phase":"phase_3","status":"active","brandName":"BNX sublingual film","genericName":"BNX sublingual film","companyName":"Orexo AB","companyId":"orexo-ab","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BNX is a buprenorphine sublingual film that binds to opioid receptors to provide analgesia and opioid dependence treatment. Used for Opioid use disorder maintenance treatment, Moderate to severe pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}