{"id":"bnt162b2-pfizer-biontech-comirnaty","brandName":"BNT162b2 Pfizer-BioNTech/Comirnaty","genericName":"BNT162b2 Pfizer-BioNTech/Comirnaty","companyId":"kk-women-s-and-children-s-hospital","companyName":"KK Women's and Children's Hospital","phase":"marketed","status":"active","modality":"Biologic","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"BNT162b2, also known as Comirnaty, is a vaccine antigen that targets the spike glycoprotein of the SARS-CoV-2 virus. It is used to prevent COVID-19, a condition studied in various clinical trials, including the COVID-19 Vaccines Safety Tracking (CoVaST) study.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine delivers lipid nanoparticle-encapsulated messenger RNA encoding the full-length spike protein of SARS-CoV-2. Upon intramuscular injection, the mRNA is translated by host cells to produce spike protein antigen, which activates both CD8+ T-cell and B-cell mediated immunity. This generates neutralizing antibodies and cellular immunity against the virus, reducing risk of infection and severe disease.","oneSentence":"BNT162b2 is an mRNA vaccine that instructs cells to produce the SARS-CoV-2 spike protein, triggering an immune response to prevent COVID-19 infection.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"71","effect":"Injection site pain"},{"rate":"59","effect":"Fatigue"},{"rate":"52","effect":"Headache"},{"rate":"38","effect":"Myalgia"},{"rate":"35","effect":"Chills"},{"rate":"14","effect":"Fever"},{"rate":"7","effect":"Lymphadenopathy"}]},"trials":[],"indications":{"approved":[{"name":"Prevention of COVID-19 in individuals 6 months of age and older"},{"name":"Booster vaccination for COVID-19 in previously vaccinated individuals"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}