{"id":"bno-1016","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BNO 1016 is a standardized extract combination from Bionorica containing multiple plant-derived compounds that work synergistically to reduce airway inflammation and support mucociliary clearance. The formulation targets multiple pathways involved in respiratory inflammation and immune regulation, making it suitable for conditions characterized by impaired airway function and excessive mucus production.","oneSentence":"BNO 1016 is a herbal combination product that modulates immune and inflammatory responses to support respiratory health.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:43:51.403Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute bronchitis with productive cough"},{"name":"Chronic obstructive pulmonary disease (COPD) exacerbations"}]},"trialDetails":[{"nctId":"NCT01706484","phase":"PHASE3","title":"Efficacy and Safety of Two Dosages of a Herbal Medicinal Product (Dry Extract BNO 1016) in Chronic Rhinosinusitis","status":"COMPLETED","sponsor":"Bionorica SE","startDate":"2012-09","conditions":"Chronic Sinusitis","enrollment":927},{"nctId":"NCT01146860","phase":"PHASE3","title":"Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis","status":"COMPLETED","sponsor":"Bionorica SE","startDate":"2010-01","conditions":"Acute Rhinosinusitis","enrollment":386}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["herbal plant extract,","sinupret extract mite","Sinupret extract"],"phase":"phase_3","status":"active","brandName":"BNO 1016","genericName":"BNO 1016","companyName":"Bionorica SE","companyId":"bionorica-se","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BNO 1016 is a herbal combination product that modulates immune and inflammatory responses to support respiratory health. Used for Acute bronchitis with productive cough, Chronic obstructive pulmonary disease (COPD) exacerbations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}