{"id":"blt","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute rejection"},{"rate":null,"effect":"Chronic rejection / graft-versus-host disease"},{"rate":null,"effect":"Immunosuppression-related infections"},{"rate":null,"effect":"Immunosuppression-related malignancy"},{"rate":null,"effect":"Surgical complications"}]},"_chembl":{"chemblId":"CHEMBL3402568","moleculeType":"Small molecule","molecularWeight":"241.40"},"_dailymed":{"setId":"3eea2171-850b-4045-e054-00144ff8d46c","title":"BLT 1 (BENZOCAINE) OINTMENT [CENTURA PHARMACEUTICALS INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BLT (Biologic Limb Transplantation) involves surgical transplantation of a whole limb or limb segment from a deceased donor to restore form and function in patients with severe limb loss. The procedure requires lifelong immunosuppression to prevent rejection of the allograft tissue. It is distinct from prosthetic limbs in that it provides living tissue with potential for nerve regeneration and functional recovery.","oneSentence":"BLT is a composite tissue allograft transplant procedure that replaces damaged or missing limbs and associated tissues with donor tissue.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:05.810Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/BLT","title":"BLT","extract":"A BLT is a type of sandwich, named for the initials of its primary ingredients, bacon, lettuce, and tomato. It can be made with varying recipes according to personal preference. Simple variants include using different types of lettuce or tomatoes, toasting or not, or adding mayonnaise. More pronounced variants include using turkey bacon or tofu in place of regular bacon, removing the lettuce entirely, or adding other ingredients such as a fried egg, avocado (BLAT), or sprouts."},"indications":{"approved":[{"name":"Severe limb loss or amputation with potential for functional restoration"},{"name":"Patients unsuitable for or unsatisfied with prosthetic alternatives"}]},"trialDetails":[{"nctId":"NCT05524961","phase":"NA","title":"Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2022-12-09","conditions":"Parkinson Disease","enrollment":69},{"nctId":"NCT04923841","phase":"NA","title":"Myopia Control Using Bright Light Therapy, Myopic Defocus and Atropine","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Hong Kong Polytechnic University","startDate":"2021-09-09","conditions":"Myopia","enrollment":579},{"nctId":"NCT05631236","phase":"NA","title":"Promoting Cognitive Resilience 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Used for Severe limb loss or amputation with potential for functional restoration, Patients unsuitable for or unsatisfied with prosthetic alternatives.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}