{"id":"blind-injection-of-mepivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Systemic toxicity (CNS effects, cardiac arrhythmias) with overdose"},{"rate":"rare","effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mepivacaine reversibly inhibits sodium influx into nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action blocks conduction of sensory, motor, and autonomic nerve impulses in the area where it is injected. The 'blind injection' technique refers to administration without direct visualization of the target nerve or tissue.","oneSentence":"Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:07.711Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and dental procedures"},{"name":"Pain relief during minor medical procedures"}]},"trialDetails":[{"nctId":"NCT06927726","phase":"NA","title":"Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Tanta University","startDate":"2025-01-10","conditions":"Hypertension","enrollment":60},{"nctId":"NCT06128590","phase":"NA","title":"Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2023-02-15","conditions":"Fear Needles","enrollment":50},{"nctId":"NCT03922412","phase":"NA","title":"Plantar Compartment Block Versus Sciatic Block in Hallux Valgus Ambulatory Surgery","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2019-06-24","conditions":"Anesthesia","enrollment":60},{"nctId":"NCT05239078","phase":"NA","title":"Comparative Evaluation of Pulpal Anaesthetic Efficacy of Different Anaesthetic Solutions for Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis","status":"COMPLETED","sponsor":"Dr. Vivek Aggarwal","startDate":"2016-03-01","conditions":"Pulpitis","enrollment":120},{"nctId":"NCT01574807","phase":"PHASE4","title":"The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2012-05","conditions":"Pain","enrollment":100},{"nctId":"NCT03046108","phase":"PHASE4","title":"Blind and Ultrasound Guided Injection in Morton Neuroma","status":"UNKNOWN","sponsor":"Complejo Hospitalario Universitario de Granada","startDate":"2016-01","conditions":"Morton Neuroma","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":199,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"blind injection of Mepivacaine","genericName":"blind injection of Mepivacaine","companyName":"Complejo Hospitalario Universitario de Granada","companyId":"complejo-hospitalario-universitario-de-granada","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for surgical and dental procedures, Pain relief during minor medical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}