{"id":"blank-maleate-entecavir-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":"rare","effect":"Lactic acidosis"},{"rate":null,"effect":"Hepatic flare"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Entecavir is a nucleoside analog that competitively inhibits the reverse transcriptase enzyme of hepatitis B virus, preventing the conversion of pregenomic RNA to viral DNA. It also inhibits the protein priming step required for initiation of HBV DNA synthesis. This dual mechanism makes it a potent inhibitor of HBV replication with activity against both wild-type and lamivudine-resistant strains.","oneSentence":"Entecavir inhibits hepatitis B virus reverse transcriptase and protein priming, blocking viral DNA replication.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:40.931Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis B infection"},{"name":"Hepatitis B with compensated liver disease"},{"name":"Hepatitis B with decompensated liver disease"}]},"trialDetails":[{"nctId":"NCT01926288","phase":"PHASE4","title":"Efficacy and Safety of Entecavir Maleate Tablets in Chinese Patients With Hepatitis B","status":"COMPLETED","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2008-10","conditions":"Chronic Hepatitis B","enrollment":287}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Blank maleate entecavir tablets","genericName":"Blank maleate entecavir tablets","companyName":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","companyId":"chia-tai-tianqing-pharmaceutical-group-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Entecavir inhibits hepatitis B virus reverse transcriptase and protein priming, blocking viral DNA replication. Used for Chronic hepatitis B infection, Hepatitis B with compensated liver disease, Hepatitis B with decompensated liver disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}