{"id":"black-cohosh","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Hepatotoxicity (rare)"}]},"_chembl":{"chemblId":"CHEMBL1093278","moleculeType":"Small molecule","molecularWeight":"737.78"},"_dailymed":{"setId":"16ecc94f-1001-983c-e063-6294a90a7b6c","title":"COMPLETE 30C/200C HOMEOPATHIC KIT (100 REMEDY KIT) KIT [WASHINGTON HOMEOPATHIC PRODUCTS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Black cohosh (Cimicifuga racemosa) contains multiple bioactive compounds that may interact with estrogen receptors or serotonergic pathways. It is traditionally used to alleviate menopausal symptoms such as hot flashes and night sweats, though clinical evidence for efficacy is mixed and the precise molecular targets have not been definitively established.","oneSentence":"Black cohosh is a botanical extract that may modulate estrogen signaling and reduce vasomotor symptoms, though its exact mechanism remains incompletely understood.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:21:53.949Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Menopausal mood and sleep disturbances"}]},"trialDetails":[{"nctId":"NCT05304416","phase":"","title":"Clinical Markers of Dysphagia in Cardiac Surgical Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2022-06-07","conditions":"Cardiovascular Diseases, Dysphagia","enrollment":347},{"nctId":"NCT05067998","phase":"","title":"The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature","status":"RECRUITING","sponsor":"Faith A. 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Cardiac Surgical Patients_","status":"WITHDRAWN","sponsor":"University of Florida","startDate":"2022-05","conditions":"Cardiovascular Diseases","enrollment":""},{"nctId":"NCT05156814","phase":"PHASE4","title":"Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women","status":"UNKNOWN","sponsor":"Scientific Research Institute of Public Health, Russian Federation","startDate":"2021-11-29","conditions":"Perimenopausal Disorder, Hot Flashes","enrollment":150},{"nctId":"NCT03461380","phase":"PHASE2","title":"Effect of Menopause Relief EP-40 in Women With Menopausal Symptoms","status":"COMPLETED","sponsor":"EuroPharma, Inc.","startDate":"2018-10-01","conditions":"Menopause","enrollment":220},{"nctId":"NCT03786809","phase":"NA","title":"Vascular Effect of CIMICIFUGA RACEMOSA","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2016-06","conditions":"Postmenopausal 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Oncology","startDate":"2003-10","conditions":"Breast Cancer, Hot Flashes","enrollment":132},{"nctId":"NCT00663104","phase":"PHASE3","title":"Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause","status":"TERMINATED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2008-04","conditions":"Bone Diseases, Metabolic Syndrome X, Coronary Disease","enrollment":126},{"nctId":"NCT02093650","phase":"PHASE3","title":"Black Cohosh Extract for Treatment of Moderate to Severe Menopausal Symptoms","status":"UNKNOWN","sponsor":"Navamindradhiraj University","startDate":"2014-03","conditions":"Menopause, Quality of Life","enrollment":60},{"nctId":"NCT01487694","phase":"PHASE3","title":"Black Cohosh Extract for the Management of Moderate to Severe Menopausal Symptoms in Thai Women","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2011-12","conditions":"Hot 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(NIA)","startDate":"2000-07","conditions":"Menopause, Hot Flashes","enrollment":355},{"nctId":"NCT00794690","phase":"NA","title":"Safety Study of Black Cohosh Use by Postmenopausal Women on the Liver","status":"COMPLETED","sponsor":"Assiut University","startDate":"2008-01","conditions":"Menopause","enrollment":100},{"nctId":"NCT00064831","phase":"PHASE1, PHASE2","title":"Black Cohosh Extract in Postmenopausal Breast Health","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2003-07","conditions":"Menopause, Hot Flashes","enrollment":73},{"nctId":"NCT00066144","phase":"PHASE2","title":"Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2003-04","conditions":"Hot Flashes, Menopause","enrollment":112},{"nctId":"NCT00010959","phase":"PHASE1","title":"Single-Dose Study of Black Cohosh and Red 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understood. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Menopausal mood and sleep disturbances.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}