{"id":"bivalent-opv-2-week-interval","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaccine-strain poliovirus shedding in stool"},{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bivalent oral polio vaccine (bOPV) contains live attenuated poliovirus strains of types 1 and 3. When administered orally, it replicates in the intestinal tract and induces both mucosal (IgA) and systemic (IgG) immune responses. The 2-week interval dosing schedule is designed to optimize immune response and achieve high population immunity levels for polio eradication.","oneSentence":"Bivalent OPV provides immunization against poliovirus types 1 and 3 by stimulating the immune system to produce antibodies against these two serotypes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:13.056Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Poliomyelitis prevention (poliovirus types 1 and 3)"}]},"trialDetails":[{"nctId":"NCT03581734","phase":"PHASE3","title":"Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine","status":"UNKNOWN","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2018-07-01","conditions":"Vaccine Reaction","enrollment":579},{"nctId":"NCT01633216","phase":"PHASE4","title":"Poliovirus Vaccine Trial in Bangladesh","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2012-05","conditions":"Healthy Infants","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Bivalent OPV 2 week interval","genericName":"Bivalent OPV 2 week interval","companyName":"International Centre for Diarrhoeal Disease Research, Bangladesh","companyId":"international-centre-for-diarrhoeal-disease-research-bangladesh","modality":"Biologic","firstApprovalDate":"","aiSummary":"Bivalent OPV provides immunization against poliovirus types 1 and 3 by stimulating the immune system to produce antibodies against these two serotypes. Used for Poliomyelitis prevention (poliovirus types 1 and 3).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}