{"id":"bitopertin-ro4917838-level-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Insomnia"}]},"_chembl":{"chemblId":"CHEMBL1171829","moleculeType":"Small molecule","molecularWeight":"543.46"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"By blocking the reuptake of glycine at the presynaptic terminal, bitopertin increases glycine concentration in the synaptic cleft. Glycine acts as a co-agonist at NMDA receptors, and elevated levels potentiate glutamatergic neurotransmission, which is hypothesized to improve cognitive and negative symptoms in schizophrenia and other neuropsychiatric disorders.","oneSentence":"Bitopertin is a glycine transporter 1 (GlyT1) inhibitor that increases synaptic glycine levels to enhance NMDA receptor function in the brain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:43:16.708Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Schizophrenia (negative and cognitive symptoms, as adjunctive therapy)"},{"name":"Autism spectrum disorder (investigational)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"bitopertin [RO4917838] level 1","genericName":"bitopertin [RO4917838] level 1","companyName":"Hoffmann-La Roche","companyId":"roche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bitopertin is a glycine transporter 1 (GlyT1) inhibitor that increases synaptic glycine levels to enhance NMDA receptor function in the brain. Used for Schizophrenia (negative and cognitive symptoms, as adjunctive therapy), Autism spectrum disorder (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}