{"id":"bismuth-subnitrate","rwe":[{"pmid":"39811205","year":"2024","title":"Iodoform in Surgical Practice: A Comprehensive Review of Its Historical Evolution, Clinical Applications, and Safety Profiles.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"38836107","year":"2024","title":"Untargeted metabolomics and metagenomics reveal signatures for intramammary ceftiofur treatment and lactation stage in the cattle hindgut.","finding":"","journal":"Frontiers in molecular biosciences","studyType":"Clinical Study"},{"pmid":"37946266","year":"2023","title":"Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.","finding":"","journal":"Animal microbiome","studyType":"Clinical Study"},{"pmid":"37641267","year":"2023","title":"Randomized, noninferiority trial evaluating the efficacy of a novel teat sealant in pasture grazed dairy cows.","finding":"","journal":"Journal of dairy science","studyType":"Clinical Study"},{"pmid":"36195011","year":"2022","title":"Fabrication of novel BiVO(4)/Bi(2)O(3)heterostructure with superior visible light induced photocatalytic properties.","finding":"","journal":"Nanotechnology","studyType":"Clinical Study"}],"tags":[{"label":"bismuth subnitrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A02BX12","category":"atc"},{"label":"Active","category":"status"},{"label":"Antacids","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"unknown","safety":{"safetySignals":[{"llr":149.515,"date":"","count":31,"signal":"Appendicolith","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=150)"},{"llr":136.261,"date":"","count":30,"signal":"Blood phosphorus increased","source":"DrugCentral FAERS","actionTaken":"Reported 30 times (LLR=136)"},{"llr":118.52,"date":"","count":31,"signal":"Appendicitis","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=119)"},{"llr":111.004,"date":"","count":32,"signal":"Ventricular fibrillation","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=111)"},{"llr":107.23,"date":"","count":25,"signal":"Myasthenia gravis","source":"DrugCentral FAERS","actionTaken":"Reported 25 times (LLR=107)"},{"llr":105.546,"date":"","count":26,"signal":"Blood uric acid increased","source":"DrugCentral FAERS","actionTaken":"Reported 26 times (LLR=106)"},{"llr":103.279,"date":"","count":32,"signal":"Cardiogenic shock","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=103)"},{"llr":82.286,"date":"","count":33,"signal":"Stress","source":"DrugCentral FAERS","actionTaken":"Reported 33 times (LLR=82)"},{"llr":81.106,"date":"","count":32,"signal":"Ascites","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=81)"},{"llr":72.042,"date":"","count":33,"signal":"Multiple organ dysfunction syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 33 times (LLR=72)"},{"llr":69.738,"date":"","count":33,"signal":"Abdominal distension","source":"DrugCentral FAERS","actionTaken":"Reported 33 times (LLR=70)"},{"llr":68.259,"date":"","count":30,"signal":"Dry mouth","source":"DrugCentral FAERS","actionTaken":"Reported 30 times (LLR=68)"}],"commonSideEffects":[{"effect":"Appendicolith","drugRate":"LLR 150","severity":"common"},{"effect":"Blood phosphorus increased","drugRate":"LLR 136","severity":"common"},{"effect":"Appendicitis","drugRate":"LLR 119","severity":"common"},{"effect":"Ventricular fibrillation","drugRate":"LLR 111","severity":"common"},{"effect":"Myasthenia gravis","drugRate":"LLR 107","severity":"common"},{"effect":"Blood uric acid increased","drugRate":"LLR 106","severity":"common"},{"effect":"Cardiogenic shock","drugRate":"LLR 103","severity":"common"},{"effect":"Stress","drugRate":"LLR 82","severity":"common"},{"effect":"Ascites","drugRate":"LLR 81","severity":"common"},{"effect":"Multiple organ dysfunction syndrome","drugRate":"LLR 72","severity":"common"},{"effect":"Abdominal distension","drugRate":"LLR 70","severity":"common"},{"effect":"Dry mouth","drugRate":"LLR 68","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["bismuth subnitrate"],"offLabel":[],"synonyms":["bismuth subnitrate"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bismuth subnitrate","explanation":"In simple terms, bismuth subnitrate is believed to help kill certain types of bacteria that can cause infections. It does this by disrupting the bacteria's ability to function and multiply, ultimately helping to clear up the infection. However, more research is needed to fully understand how bismuth subnitrate works and how it compares to other treatments.","oneSentence":"Bismuth subnitrate is thought to work by exerting antimicrobial properties, although the exact mechanism is unclear.","technicalDetail":"Bismuth subnitrate's mechanism of action is thought to involve the inhibition of bacterial enzymes and the disruption of bacterial cell membranes, although the exact molecular details are unclear."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Bismuth_oxynitrate","title":"Bismuth oxynitrate","extract":"Bismuth oxynitrate is the name applied to a number of compounds that contain Bi3+, nitrate ions and oxide ions and which can be considered as compounds formed from Bi2O3, N2O5 and H2O. Other names for bismuth oxynitrate include bismuth subnitrate and bismuthyl nitrate. In older texts bismuth oxynitrate is often simply described as BiONO3 or basic bismuth nitrate. Bismuth oxynitrate was once called magisterium bismuti or bismutum subnitricum, and was used as a white pigment, in beauty care, and as a gentle disinfectant for internal and external use. It is also used to form Dragendorff's reagent, which is used as a TLC stain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4841","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=bismuth%20subnitrate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=bismuth subnitrate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Bismuth_oxynitrate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:04:05.830821","biosimilars":[],"competitors":[{"drugName":"sucralfate","drugSlug":"sucralfate","fdaApproval":"1981-10-30","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bismuth subcitrate","drugSlug":"bismuth-subcitrate","fdaApproval":"2006-09-28","relationship":"same-class"}],"genericName":"bismuth subnitrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sucralfate","brandName":"sucralfate","genericName":"sucralfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"bismuth-subcitrate","brandName":"bismuth subcitrate","genericName":"bismuth subcitrate","approvalYear":"2006","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02726360","phase":"","title":"Physician Use of Non-English Language Skills in Cancer Care","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2015-12-14","conditions":["Breast Cancer","Colon Cancer","Lung Cancer"],"enrollment":71,"completionDate":"2023-08-21"},{"nctId":"NCT00943813","phase":"","title":"Assessment of Comskil Training Through Videorecording and Patient Surveys","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2009-05","conditions":["Comskil Training"],"enrollment":55,"completionDate":"2016-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000147275","MMSL":"4289","NDDF":"001913","UNII":"H19J064BA5","VUID":"4018999","CHEBI":"CHEBI:31293","VANDF":"4018999","RXNORM":"19477","UMLSCUI":"C0053791","ChEMBL_ID":"CHEMBL3833348","KEGG_DRUG":"D01642","DRUGBANK_ID":"DB13209","PUBCHEM_CID":"18503857","SNOMEDCT_US":"391852006","MESH_SUPPLEMENTAL_RECORD_UI":"C010804"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":180,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"A02BX12","allCodes":["A02BX12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Dec","pmid":"39811205","title":"Iodoform in Surgical Practice: A Comprehensive Review of Its Historical Evolution, Clinical Applications, and Safety Profiles.","journal":"Cureus"},{"date":"2024","pmid":"38836107","title":"Untargeted metabolomics and metagenomics reveal signatures for intramammary ceftiofur treatment and lactation stage in the cattle hindgut.","journal":"Frontiers in molecular biosciences"},{"date":"2023 Nov 9","pmid":"37946266","title":"Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.","journal":"Animal microbiome"},{"date":"2023 Dec","pmid":"37641267","title":"Randomized, noninferiority trial evaluating the efficacy of a novel teat sealant in pasture grazed dairy cows.","journal":"Journal of dairy science"},{"date":"2022 Oct 21","pmid":"36195011","title":"Fabrication of novel BiVO(4)/Bi(2)O(3)heterostructure with superior visible light induced photocatalytic properties.","journal":"Nanotechnology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"bismuth subnitrate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Bismuth subnitrate is a small molecule compound with the synonyms including bismuth subnitrate, heavy bismuth subnitrate, and bismuthum subnitrucum. It has been studied in clinical trials for various conditions, including breast cancer, colon cancer, and lung cancer, as part of the Comskil Training assessment through videorecording and patient surveys.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}