{"id":"bisacodyl-peg-cs","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Electrolyte imbalance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bisacodyl is a diphenolic laxative that acts as a contact stimulant, increasing intestinal motility and promoting bowel evacuation. PEG-CS is an osmotic agent that draws water into the intestinal lumen, softening stool and facilitating cleansing. Together, they provide both mechanical stimulation and osmotic hydration for bowel preparation.","oneSentence":"Bisacodyl stimulates colonic muscle contractions while PEG-CS (polyethylene glycol with electrolytes) provides osmotic laxation and bowel cleansing.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:37.939Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy or other gastrointestinal procedures"},{"name":"Constipation management"}]},"trialDetails":[{"nctId":"NCT03146052","phase":"NA","title":"Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation","status":"COMPLETED","sponsor":"ASST Rhodense","startDate":"2017-03-27","conditions":"Polyps, Colon Preparation","enrollment":81},{"nctId":"NCT02040285","phase":"PHASE4","title":"Low-dose Laxative Improves Performance and Feasibility of Computed Tomography Colonography (CTC)","status":"COMPLETED","sponsor":"Azienda Policlinico Umberto I","startDate":"2012-02","conditions":"Gastrointestinal Complication","enrollment":52},{"nctId":"NCT01711437","phase":"PHASE4","title":"Different Bowel Preparations for Colonoscopy In Children","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2011-01","conditions":"Colonoscopy","enrollment":400},{"nctId":"NCT01685853","phase":"PHASE3","title":"Bowel Cleansing for Colonoscopy: Comparison Between a Same Day Low-Volume Preparation and a Conventional 4L Split One","status":"COMPLETED","sponsor":"European Institute of Oncology","startDate":"2011-04","conditions":"Colonoscopy","enrollment":164},{"nctId":"NCT01509131","phase":"PHASE4","title":"Evaluation of a Mixed Bowel Prep (2L PEG + Bisacodyl) Versus PEG With Ascorbate","status":"COMPLETED","sponsor":"Promefarm S.r.l.","startDate":"2010-03","conditions":"Colonoscopy","enrollment":408}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lovoldyl (Bisacodyl)","Lovolesse (PEG-CS)","Gastromiro (Iopamidol)","Plasil (Metoclopramide mono chlorohydrate monohydrate)"],"phase":"marketed","status":"active","brandName":"Bisacodyl & PEG-CS","genericName":"Bisacodyl & PEG-CS","companyName":"Azienda Policlinico Umberto I","companyId":"azienda-policlinico-umberto-i","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bisacodyl is used in combination with PEG-CS (a solution of polyethylene glycol 4000 added with citrates and simethicone) for bowel preparation, particularly for colonoscopy. This combination is studied for its effectiveness in conditions such as colon polyps, gastrointestinal complications, and colon preparation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}