{"id":"bisacodyl","rwe":[],"_fda":{"id":"485ea50e-b62c-cbb9-e063-6394a90a1cdf","set_id":"015e41d2-7543-4210-8345-626f5ae5f81d","openfda":{"nui":["N0000009371","N0000175812","N0000009871"],"upc":["0311917162638"],"unii":["10X0709Y6I"],"route":["RECTAL"],"rxcui":["198509"],"spl_id":["485ea50e-b62c-cbb9-e063-6394a90a1cdf"],"brand_name":["Walgreens Gentle Laxative"],"spl_set_id":["015e41d2-7543-4210-8345-626f5ae5f81d"],"package_ndc":["0363-0466-30"],"product_ndc":["0363-0466"],"generic_name":["BISACODYL SUPPOSITORY"],"product_type":["HUMAN OTC DRUG"],"pharm_class_pe":["Increased Large Intestinal Motility [PE]","Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]"],"substance_name":["BISACODYL"],"pharm_class_epc":["Stimulant Laxative [EPC]"],"manufacturer_name":["Walgreens"],"application_number":["M007"],"is_original_packager":[true]},"purpose":["Uses -for relief of occasional constipation -this product generally produces bowel movement in 1/4 to 1 hour"],"version":"6","stop_use":["Stop use and ask a doctor if Stop use and ask a doctor if -you have rectal bleeding -you fail to have a bowel movement after using this product. This may indicate a serious condition"],"warnings":["Warnings For rectal use only."],"ask_doctor":["Ask a doctor Ask a doctor before use if you have noticed a sudden change in bowel habits that lasts over a period of 2 weeks"],"do_not_use":["Do not use Do not use -when abdominal pain, nausea, or vomiting are present -for a period of longer than 1 week"],"when_using":["When using this product When using this product it may cause abdominal discomfort, faintness, rectal burning and mild cramps"],"effective_time":"20260115","active_ingredient":["Active Ingredient (in each Suppository) Active Ingredient Purpose (in each Suppository) Bisacodyl 10 mg.................................Stimulant Laxative"],"inactive_ingredient":["Inactive ingredient Inactive ingredient hydrogenated vegetable oil"],"storage_and_handling":["Other information Other information -Store at room temperature. Do not exceed 30 o C (86 o F) -Lot No. & Exp. Date: see wrapper or box"],"indications_and_usage":["Directions -detach one suppository from the strip -remove wrapper before inserting into the rectum adults and children 12 years of age and older 1 suppository once daily children 6 to under 12 years 1/2 suppository once daily children under 6 years do not use"],"dosage_and_administration":["Directions -detach one suppository from the strip -remove wrapper before inserting into the rectum adults and children 12 years of age and older 1 suppository once daily children 6 to under 12 years 1/2 suppository once daily children under 6 years do not use"],"spl_product_data_elements":["Walgreens Gentle Laxative Bisacodyl Suppository PALM KERNEL OIL BISACODYL DEACETYLBISACODYL"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding If pregnant or breast-feeding, ask a health professional before use."],"keep_out_of_reach_of_children":["Keep out of reach of children Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["Label Product Label"]},"tags":[{"label":"Stimulant Laxative","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Kappa-type opioid receptor","category":"target"},{"label":"OPRK1","category":"gene"},{"label":"SLC6A3","category":"gene"},{"label":"CYP2C9","category":"gene"},{"label":"A06AB02","category":"atc"},{"label":"Oral","category":"route"},{"label":"Rectal","category":"route"},{"label":"Capsule","category":"form"},{"label":"Enema","category":"form"},{"label":"Pill","category":"form"},{"label":"Suppository","category":"form"},{"label":"Active","category":"status"},{"label":"Constipation","category":"indication"},{"label":"Incomplete passage of stool","category":"indication"},{"label":"Braintree","category":"company"},{"label":"Approved 2000s","category":"decade"},{"label":"Cathartics","category":"pharmacology"},{"label":"Gastrointestinal 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(Braintree)"}],"brandName":"Halflytely","ecosystem":[{"indication":"Constipation","otherDrugs":[{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"glycerol","slug":"glycerol","company":"B Braun"},{"name":"homatropine","slug":"homatropine","company":""}],"globalPrevalence":null},{"indication":"Incomplete passage of stool","otherDrugs":[{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"homatropine","slug":"homatropine","company":""},{"name":"macrogol","slug":"macrogol","company":"Braintree"},{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"}],"globalPrevalence":null}],"mechanism":{"target":"Kappa-type opioid receptor","novelty":"Follow-on","targets":[{"gene":"OPRK1","source":"DrugCentral","target":"Kappa-type opioid receptor","protein":"Kappa-type opioid receptor"},{"gene":"SLC6A3","source":"DrugCentral","target":"Sodium-dependent dopamine 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It is usually followed by a number indicating the average molecular weight, indicating the length of the polymer of the specific molecule in use. Macrogol is used as a laxative to treat constipation in children and adults. It is taken by mouth. Benefits usually occur within three days. It is also used as an excipient. It is also used to clear the bowels before a colonoscopy, when the onset of the laxative effect is more rapid, typically within an hour."},"commercial":{"launchDate":"2004","_launchSource":"DrugCentral (FDA 2004-05-10, 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