{"id":"biriperone","rwe":[],"tags":[{"label":"biriperone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(3) dopamine receptor","category":"target"},{"label":"DRD3","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"centbutindole","offLabel":[],"synonyms":["biriperone","centbutindole"],"timeline":[],"aiSummary":"Centbutindole, also known as biriperone, is a small molecule targeting the D(3) dopamine receptor. It is a biriperone drug class, but its current status and indications are unknown. As a small molecule, it is likely to have a specific mechanism of action, but its commercial status and safety considerations are not well-documented. Further research is needed to understand its potential therapeutic applications and risks. Its exact pharmacokinetic properties, such as half-life and bioavailability, are also unknown.","brandName":"Centbutindole","ecosystem":[],"mechanism":{"target":"D(3) dopamine receptor, 5-hydroxytryptamine receptor 2A, D(1A) dopamine receptor","targets":[{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"}],"modality":"Small Molecule","drugClass":"biriperone","explanation":"Imagine your brain has a system for controlling movement and emotions, and dopamine is a key chemical that helps it work. Centbutindole blocks the D(3) dopamine receptor, which can affect how this system functions. This can potentially help with conditions related to abnormal movement or dopamine imbalances.","oneSentence":"Centbutindole works by binding to the D(3) dopamine receptor, which is involved in regulating movement and other functions in the brain.","technicalDetail":"Centbutindole acts as a selective antagonist at the D(3) dopamine receptor, which is a subtype of dopamine receptor involved in regulating movement, motivation, and reward processing."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3883","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIRIPERONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:00:35.624270","biosimilars":[],"competitors":[{"drugName":"amifostine","drugSlug":"amifostine","fdaApproval":"1995-12-08","genericCount":2,"patentStatus":"Off-patent — generic 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