{"id":"biotin","rwe":[{"pmid":"41903118","year":"2026","title":"Directed Evolution Improves the Catalytic Efficiency of APEX2-Mediated Proximity-Dependent RNA Labeling.","finding":"","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","studyType":"Clinical Study"},{"pmid":"41901986","year":"2026","title":"Real-Time Probing of Molecular Affinity Using Optical Tweezers.","finding":"","journal":"Sensors (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41899409","year":"2026","title":"Quantification of the Human Satellite 2 (HSAT2) Repeat in the Plasma Cell-Free DNA of Patients with Colon Cancer.","finding":"","journal":"Current issues in molecular biology","studyType":"Clinical Study"},{"pmid":"41895687","year":"2026","title":"Impact of spacer chain length on self-assembly of paclitaxel-biotin conjugates.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"41895295","year":"2026","title":"Engineering Disorder in Droplet Packings through Polydispersity and Adhesion.","finding":"","journal":"ACS applied materials & interfaces","studyType":"Clinical Study"}],"_fda":{"id":"d9913eda-a019-4227-9dd3-9e8358dec165","set_id":"06508e37-5ae6-4a17-bf60-b3828c6082a7","openfda":{"nui":["N0000193618","M0001797"],"upc":["0105420121004"],"unii":["PQ6CK8PD0R","6SO6U10H04","568ET80C3D","8406EY2OQA","935E97BOY8","25X51I8RD4","68Y4CF58BV","TLM2976OFR","8K0I04919X","K72I3DEX9B"],"route":["ORAL"],"spl_id":["d9913eda-a019-4227-9dd3-9e8358dec165"],"brand_name":["Dialyvite with Zinc"],"spl_set_id":["06508e37-5ae6-4a17-bf60-b3828c6082a7"],"package_ndc":["10542-012-10","10542-012-02"],"product_ndc":["10542-012"],"generic_name":["ASCORBIC ACID, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE, FOLIC ACID, COBALAMIN, BIOTIN, PANTOTHENIC ACID, ZINC"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]"],"substance_name":["ASCORBIC ACID","BIOTIN","CALCIUM PANTOTHENATE","COBALAMIN","FOLIC ACID","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","THIAMINE MONONITRATE","ZINC CITRATE"],"pharm_class_epc":["Vitamin C [EPC]"],"manufacturer_name":["Hillestad Pharmaceuticals USA"],"is_original_packager":[true]},"version":"5","description":["DESCRIPTION Dialyvite with Zinc is a prescription folic acid supplement with zinc and additional nutrients for kidney dialysis patients. Dialyvite with Zinc is a small, round, yellow, clear-coated tablet, with debossed \"H\" on one side. Each tablet contains: Folic Acid.....1 mg Vitamin C (Ascorbic Acid).....100 mg Thiamine (Thiamine Mononitrate).....1.5 mg Riboflavin.....1.7 mg Niacinamide.....20 mg Vitamin B6 (Pyridoxine HCl).....10 mg Vitamin B12 (Methylcobalamin).....6 mcg Biotin.....300 mcg Pantothenic Acid (Calcium Pantothenate).....10 mg Zinc (Zinc Citrate).....50 mg Inactive ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Mono-and Diglycerides, Pharmaceutical Glaze, Starch, Calcium Stearate."],"precautions":["PRECAUTIONS Folic acid supplementation may obscure pernicious anemia, in that hematologic remission can occur while neurological manifestations progress. Keep out of reach of children."],"effective_time":"20260127","adverse_reactions":["ADVERSE REACTIONS Allergic sensitizations have been reported following oral administration of folic acid. Consult your physician immediately if adverse side effects occur."],"contraindications":["CONTRAINDICATIONS This product is contraindicated in patients with known hypersensitivity to any of the ingredients."],"indications_and_usage":["INDICATIONS AND USAGE Dialyvite with Zinc is a prescription folic acid supplement with Zinc and additional nutrients indicated for use in improving the nutritional status of renal dialysis patients."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Take one tablet per day or as directed by your physician, orally."],"spl_product_data_elements":["Dialyvite with Zinc Ascorbic Acid, Thiamine, Riboflavin, Niacinamide, Pyridoxine, Folic Acid, Cobalamin, Biotin, Pantothenic Acid, Zinc Ascorbic Acid Ascorbic Acid Thiamine Mononitrate Thiamine Ion Thiamine Riboflavin Riboflavin Niacinamide Niacinamide Pyridoxine Hydrochloride Pyridoxine Folic Acid Folic Acid Cobalamin Cobalamin Biotin Biotin Calcium Pantothenate Pantothenic Acid Zinc Citrate Zinc Cation Microcrystalline Cellulose Croscarmellose Sodium Glyceryl Monostearate Shellac Starch, Corn Calcium Stearate H"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 10542-012-10 Dialyvite with Zinc Multivitamin Supplement for Dialysis Patients 100 Tablets Dialyvite with Zinc PDP"]},"tags":[{"label":"biotin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Insulin-degrading enzyme","category":"target"},{"label":"IDE","category":"gene"},{"label":"A11HA05","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Active","category":"status"},{"label":"Biotin deficiency disease","category":"indication"},{"label":"Hospira","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamin B Complex","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"3085 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"2303 reports"},{"date":"","signal":"ALOPECIA","source":"FDA FAERS","actionTaken":"2203 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"2157 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"1985 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"1959 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"1749 reports"},{"date":"","signal":"DIZZINESS","source":"FDA FAERS","actionTaken":"1598 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"1497 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"1439 reports"}],"commonSideEffects":[{"effect":"Gastrointestinal disturbances","drugRate":"","severity":"serious","_validated":false,"_confidence":0.3},{"effect":"Allergic sensitizations","drugRate":"","severity":"serious","_validated":false,"_confidence":0.3},{"effect":"Gastrointestinal intolerance","drugRate":"","severity":"serious","_validated":false,"_confidence":0.3},{"effect":"Nausea","drugRate":"occasionally","severity":"common"},{"effect":"Diarrhea","drugRate":"occasionally","severity":"common"},{"effect":"Constipation","drugRate":"occasionally","severity":"common"},{"effect":"Anorexia","drugRate":"occasionally","severity":"common"}],"contraindications":["Constipation","Dehydration","Hypercalcemia","Hyperparathyroidism","Kidney disease","Kidney stone","Osteolysis","Sarcoidosis"],"specialPopulations":{"Pregnancy":"Pregnant women should follow the U.S. recommended daily allowances for pregnancy because their vitamin requirements may exceed those of non-pregnant women. INFUVITE PEDIATRIC has not been studied in pregnant women. Animal reproduction studies have not been conducted with INFUVITE PEDIATRIC (multiple vitamins injection). INFUVITE ADULT should be given to pregnant woman only if clearly needed.","Geriatric use":"No clinical studies have been performed in patients age 65 and over to determine whether older persons respond differently from younger persons. Dosage should always begin at the low end of the dosage scale and should consider that elderly persons may have decreased hepatic, renal, or cardiac function and or concomitant diseases.","Paediatric use":"INFUVITE PEDIATRIC is approved for the prevention of vitamin deficiency in pediatric patients up to 11 years old receiving parenteral nutrition. INFUVITE PEDIATRIC has not been studied in pediatric patients older than 11 years. INFUVITE PEDIATRIC contains aluminum that may be toxic for premature neonates. Aluminum levels should be monitored periodically during administration of INFUVITE PEDIATRIC to premature neonates. Additional vitamin supplementations of infants receiving INFUVITE PEDIATRIC may result in elevations of vitamin levels.","Renal impairment":"Monitor renal function, calcium, phosphorus and vitamin levels.","Hepatic impairment":"Monitor vitamin levels."}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=BIOTIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:29:32.986843+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:29:39.897815+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T03:29:31.532869+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIOTIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:29:41.350307+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:29:30.394514+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:29:30.394570+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:29:30.394588+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T03:29:42.941978+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL857/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:29:41.867485+00:00"}},"allNames":"infuvite adult","offLabel":[],"synonyms":["biotin","coenzyme R","D-Biotin"],"timeline":[{"date":"1953-02-20","type":"positive","source":"DrugCentral","milestone":"FDA approval (Hospira)"}],"brandName":"Infuvite Adult","ecosystem":[{"indication":"Biotin deficiency disease","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Insulin-degrading enzyme","novelty":"First-in-class","targets":[{"gene":"IDE","source":"DrugCentral","target":"Insulin-degrading enzyme","protein":"Insulin-degrading enzyme"}],"modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Infuvite Adult (BIOTIN) acts as a competitive inhibitor of the insulin-degrading enzyme, preventing the breakdown of biotin and allowing it to accumulate in the body and exert its biological effects."},"commercial":{"launchDate":"1953","_launchSource":"DrugCentral (FDA 1953-02-20, HOSPIRA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/373","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BIOTIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIOTIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:00:03.124133","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:29:46.313231+00:00","fieldsConflicting":4,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"nicotinamide","drugSlug":"nicotinamide","fdaApproval":"1953-02-20","relationship":"same-class"},{"drugName":"pyridoxine","drugSlug":"pyridoxine","fdaApproval":"1993-12-29","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"Vitamin 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