{"id":"biotene-oral-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild oral irritation"},{"rate":null,"effect":"Taste alteration"},{"rate":null,"effect":"Temporary stinging sensation"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Biotene contains a water-based formulation with enzymes (including glucose oxidase, lactoperoxidase, and lysozyme) and electrolytes that mimic natural saliva composition. It provides immediate moisturizing relief and helps maintain oral pH balance and antimicrobial protection in patients with insufficient natural saliva production.","oneSentence":"Biotene oral spray provides lubrication and moisture to the oral cavity to relieve symptoms of dry mouth (xerostomia).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:01.582Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Xerostomia (dry mouth) due to radiation therapy, chemotherapy, Sjögren's syndrome, or other causes"}]},"trialDetails":[{"nctId":"NCT04186806","phase":"NA","title":"Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2019-11-02","conditions":"Xerostomia","enrollment":40},{"nctId":"NCT04608773","phase":"NA","title":"Blinded Dry Mouth Spray Crossover Study","status":"COMPLETED","sponsor":"Jonas Johnson","startDate":"2021-01-14","conditions":"Xerostomia, Head and Neck Cancer, Xerostomia Following Radiotherapy","enrollment":129},{"nctId":"NCT00595933","phase":"PHASE1","title":"Comparing Over-the-counter Dry Mouth Remedies After Radiation","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2005-03","conditions":"Xerostomia","enrollment":28},{"nctId":"NCT03663231","phase":"NA","title":"Duration of Effect of Biotene Spray in Patients With Dry Mouth","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2019-02-11","conditions":"Dry Mouth","enrollment":37},{"nctId":"NCT03494985","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-09-17","conditions":"Xerostomia","enrollment":422},{"nctId":"NCT02522936","phase":"PHASE4","title":"Use of Biotene Moisturizing Mouth Spray for Xerostomia Associated With Oral Oxybutynin Use","status":"WITHDRAWN","sponsor":"University of Southern California","startDate":"2018-08-01","conditions":"Overactive Bladder, Xerostomia, Compliance","enrollment":""},{"nctId":"NCT02049112","phase":"PHASE4","title":"A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study","status":"COMPLETED","sponsor":"Unither Pharmaceuticals, France","startDate":"2012-01","conditions":"Xerostomia, Hyposalivation, Head and Neck Cancer","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Biotene","Mouth spray"],"phase":"marketed","status":"active","brandName":"Biotene oral spray","genericName":"Biotene oral spray","companyName":"University of Southern California","companyId":"university-of-southern-california","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Biotene oral spray provides lubrication and moisture to the oral cavity to relieve symptoms of dry mouth (xerostomia). Used for Xerostomia (dry mouth) due to radiation therapy, chemotherapy, Sjögren's syndrome, or other causes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}