{"id":"biostate-rp","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Infusion site reactions"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Pain"}]},"_chembl":{"chemblId":"CHEMBL5483030","moleculeType":null,"molecularWeight":"468.94"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by inhibiting the C1 esterase complex, which is involved in the activation of the complement system and the release of bradykinin, a potent vasodilator. This leads to decreased levels of bradykinin and reduced inflammation in blood vessels, alleviating symptoms of hereditary angioedema.","oneSentence":"Biostate is a recombinant human C1 esterase inhibitor used to treat hereditary angioedema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:24:21.942Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hereditary angioedema"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Biostate®","Human Coagulation Factor VIII / von Willebrand Factor"],"phase":"phase_2","status":"active","brandName":"Biostate® [RP]","genericName":"Biostate® [RP]","companyName":"CSL Behring","companyId":"csl-behring","modality":"Biologic","firstApprovalDate":"","aiSummary":"Biostate is a recombinant human C1 esterase inhibitor used to treat hereditary angioedema. Used for Hereditary angioedema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}