{"id":"biofarma-bivalent-oral-poliomyelitis-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Local or systemic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains live attenuated poliovirus strains (types 1 and 3) administered orally, which replicate in the intestinal mucosa and induce both local secretory IgA antibodies and systemic IgG responses. This dual immune response provides protection against infection and transmission of the targeted poliovirus serotypes. The oral route allows for convenient mass vaccination campaigns, particularly in resource-limited settings.","oneSentence":"This bivalent oral polio vaccine stimulates mucosal and systemic immune responses against poliovirus types 1 and 3 to prevent poliomyelitis infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:24.073Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of poliomyelitis caused by poliovirus types 1 and 3"}]},"trialDetails":[{"nctId":"NCT02434770","phase":"PHASE3","title":"Immunogenicity and Safety of Liquid Bivalent Oral Poliomyelitis Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2015-08","conditions":"Poliomyelitis","enrollment":750}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BioFarma Bivalent Oral Poliomyelitis Vaccine","genericName":"BioFarma Bivalent Oral Poliomyelitis Vaccine","companyName":"PATH","companyId":"path","modality":"Biologic","firstApprovalDate":"","aiSummary":"This bivalent oral polio vaccine stimulates mucosal and systemic immune responses against poliovirus types 1 and 3 to prevent poliomyelitis infection. Used for Prevention of poliomyelitis caused by poliovirus types 1 and 3.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}