{"id":"bimatoprost-vehicle","safety":{"commonSideEffects":[{"rate":"25-45","effect":"Conjunctival hyperemia"},{"rate":"10-50","effect":"Iris hyperpigmentation"},{"rate":"3-10","effect":"Eyelash growth (hypertrichosis)"},{"rate":"10-20","effect":"Eye irritation/discomfort"},{"rate":"5-15","effect":"Foreign body sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bimatoprost binds to prostaglandin F (FP) receptors on the ciliary muscle bundle and trabecular meshwork, enhancing drainage of aqueous humor through the uveoscleral (unconventional) pathway. This increased outflow reduces intraocular pressure, making it effective for glaucoma and ocular hypertension. The vehicle formulation is the inactive carrier system used to deliver bimatoprost to the eye.","oneSentence":"Bimatoprost is a prostaglandin F analog that increases uveoscleral outflow of aqueous humor to reduce intraocular pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:32.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT04499248","phase":"PHASE1, PHASE2","title":"AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension","status":"RECRUITING","sponsor":"AbbVie","startDate":"2020-11-16","conditions":"Open-angle Glaucoma, Ocular Hypertension","enrollment":96},{"nctId":"NCT02250651","phase":"PHASE3","title":"Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-12-15","conditions":"Glaucoma, 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Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}