{"id":"bimatoprost-sr","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Conjunctival hyperemia"},{"rate":"10-25","effect":"Iris pigmentation increase"},{"rate":"10-25","effect":"Eyelash growth (hypertrichosis)"},{"rate":"10-20","effect":"Eye irritation/discomfort"},{"rate":"5-15","effect":"Periocular skin pigmentation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bimatoprost binds to prostaglandin F (FP) receptors on the ciliary muscle and trabecular meshwork, enhancing drainage of fluid from the eye through the uveoscleral pathway. The sustained-release (SR) formulation is designed to provide prolonged drug delivery, maintaining therapeutic intraocular pressure reduction over an extended dosing interval. This mechanism makes it effective for glaucoma and ocular hypertension management.","oneSentence":"Bimatoprost is a prostaglandin F analog that increases uveoscleral outflow of aqueous humor to reduce intraocular pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:24.071Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT04499248","phase":"PHASE1, PHASE2","title":"AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension","status":"RECRUITING","sponsor":"AbbVie","startDate":"2020-11-16","conditions":"Open-angle Glaucoma, Ocular Hypertension","enrollment":96},{"nctId":"NCT03891446","phase":"PHASE3","title":"Long-term Safety and Efficacy Extension Trial of Bimatoprost SR","status":"ACTIVE_NOT_RECRUITING","sponsor":"AbbVie","startDate":"2019-03-27","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":455},{"nctId":"NCT03850782","phase":"PHASE3","title":"Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"AbbVie","startDate":"2019-02-28","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":515},{"nctId":"NCT02507687","phase":"PHASE3","title":"Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"AbbVie","startDate":"2015-08-27","conditions":"Glaucoma, Open-Angle, Ocular Hypertension","enrollment":240},{"nctId":"NCT04285580","phase":"PHASE3","title":"A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"AbbVie","startDate":"2020-06-11","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":37},{"nctId":"NCT02636946","phase":"PHASE3","title":"A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Allergan","startDate":"2016-02-24","conditions":"Glaucoma, Open-Angle Ocular Hypertension","enrollment":144},{"nctId":"NCT02250651","phase":"PHASE3","title":"Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-12-15","conditions":"Glaucoma, Open-Angle, Ocular Hypertension","enrollment":528},{"nctId":"NCT02247804","phase":"PHASE3","title":"Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-12-15","conditions":"Glaucoma, Open-Angle, Ocular Hypertension","enrollment":594}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lumigan","AGN-192024","DURYSTA"],"phase":"phase_3","status":"active","brandName":"Bimatoprost (SR)","genericName":"Bimatoprost (SR)","companyName":"AbbVie","companyId":"abbvie","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bimatoprost is a prostaglandin F analog that increases uveoscleral outflow of aqueous humor to reduce intraocular pressure. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}