{"id":"bimatoprost-implant-system","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Increased iris pigmentation"},{"rate":null,"effect":"Eyelash growth"}]},"_chembl":{"chemblId":"CHEMBL1200963","moleculeType":"Small molecule","molecularWeight":"415.57"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bimatoprost binds to prostaglandin F (FP) receptors on the ciliary muscle and trabecular meshwork, enhancing drainage of aqueous humor through the uveoscleral (unconventional) pathway. The implant system provides sustained, long-acting delivery of bimatoprost directly to the eye, maintaining therapeutic intraocular pressure reduction over an extended period without daily topical administration.","oneSentence":"Bimatoprost is a prostaglandin F analog that increases uveoscleral outflow of aqueous humor to reduce intraocular pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:20.368Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT07218796","phase":"PHASE3","title":"Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)","status":"RECRUITING","sponsor":"SpyGlass Pharma, Inc.","startDate":"2025-10-28","conditions":"Cataract, Glaucoma, Ocular Hypertension","enrollment":400},{"nctId":"NCT07218783","phase":"PHASE3","title":"Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)","status":"RECRUITING","sponsor":"SpyGlass Pharma, Inc.","startDate":"2025-10-15","conditions":"Cataract, Glaucoma, Ocular Hypertension","enrollment":400},{"nctId":"NCT07154797","phase":"NA","title":"Evaluation of the Safety and Effectiveness of the Bimatoprost Implant System / IOL Combination in Patients With Ocular Hypertension or Mild to Moderate Open-angle Glaucoma","status":"COMPLETED","sponsor":"SpyGlass Pharma, Inc.","startDate":"2022-04-21","conditions":"Cataract, Ocular Hypertension, Glaucoma","enrollment":24},{"nctId":"NCT07154810","phase":"","title":"Observational Study to Evaluate Long Term Outcomes for Ocular Hypertension and Glaucoma Patients Treated With the SpyGlass Bimatoprost Implant System / IOL Combination","status":"ACTIVE_NOT_RECRUITING","sponsor":"SpyGlass Pharma, Inc.","startDate":"2023-03-16","conditions":"Glaucoma, Cataract, Ocular Hypertension","enrollment":23},{"nctId":"NCT06120842","phase":"PHASE1, PHASE2","title":"Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution","status":"ACTIVE_NOT_RECRUITING","sponsor":"SpyGlass Pharma, Inc.","startDate":"2023-10-13","conditions":"Cataract, Glaucoma, Ocular Hypertension","enrollment":201}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Bimatoprost Implant System","genericName":"Bimatoprost Implant System","companyName":"SpyGlass Pharma, Inc.","companyId":"spyglass-pharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bimatoprost is a prostaglandin F analog that increases uveoscleral outflow of aqueous humor to reduce intraocular pressure. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}