{"id":"bifonazole-cream-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an imidazole antifungal agent, bifonazole works by blocking the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in the fungal sterol synthesis pathway. This disruption leads to depletion of ergosterol, a critical component of the fungal cell membrane, causing membrane instability and ultimately fungal cell death. The topical cream formulation allows direct application to affected skin areas.","oneSentence":"Bifonazole inhibits fungal cell membrane synthesis by disrupting ergosterol production through inhibition of lanosterol 14α-demethylase.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:21.212Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal skin infections (dermatophytosis, candidiasis, pityriasis versicolor)"},{"name":"Topical treatment of tinea pedis, tinea corporis, and tinea cruris"}]},"trialDetails":[{"nctId":"NCT02705664","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-01","conditions":"Foot Dermatoses","enrollment":22},{"nctId":"NCT00781820","phase":"PHASE3","title":"Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-10","conditions":"Onychomycosis","enrollment":693}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Bifonazole cream 1%","genericName":"Bifonazole cream 1%","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bifonazole inhibits fungal cell membrane synthesis by disrupting ergosterol production through inhibition of lanosterol 14α-demethylase. Used for Fungal skin infections (dermatophytosis, candidiasis, pityriasis versicolor), Topical treatment of tinea pedis, tinea corporis, and tinea cruris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}