{"id":"bifonazole","rwe":[],"tags":[{"label":"bifonazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Steroid 17-alpha-hydroxylase/17,20 lyase","category":"target"},{"label":"CYP17A1","category":"gene"},{"label":"CYP51A1","category":"gene"},{"label":"CYP3A4","category":"gene"},{"label":"D01AC10","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bifazol","offLabel":[],"synonyms":["bifonazole","(+/-)-Bifonazole","bifazol","trifonazole"],"timeline":[],"brandName":"Bifazol","ecosystem":[],"mechanism":{"target":"Indoleamine 2,3-dioxygenase 1, Lanosterol 14-alpha demethylase, Cytochrome P450 3A4","targets":[{"gene":"CYP17A1","source":"DrugCentral","target":"Steroid 17-alpha-hydroxylase/17,20 lyase","protein":"Steroid 17-alpha-hydroxylase/17,20 lyase"},{"gene":"CYP51A1","source":"DrugCentral","target":"Lanosterol 14-alpha demethylase","protein":"Lanosterol 14-alpha demethylase"},{"gene":"CYP3A4","source":"DrugCentral","target":"Cytochrome P450 3A4","protein":"Cytochrome P450 3A4"},{"gene":"IDO1","source":"DrugCentral","target":"Indoleamine 2,3-dioxygenase 1","protein":"Indoleamine 2,3-dioxygenase 1"}],"modality":"Small Molecule","drugClass":"bifonazole","explanation":"Think of it like a traffic cop: bifazol blocks the enzyme that helps make certain steroids, which can contribute to fungal infections. By blocking this enzyme, bifazol reduces the amount of steroids available to the fungus, making it harder for the infection to grow and spread.","oneSentence":"Bifazol works by inhibiting the enzyme steroid 17-alpha-hydroxylase/17,20 lyase, which is involved in the production of steroids in the body.","technicalDetail":"Bifazol specifically inhibits the activity of the CYP17 enzyme, which is responsible for catalyzing the 17-alpha-hydroxylation and 17,20 desmolase reactions in the biosynthesis of steroids, including cortisol and androgens."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/370","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BIFONAZOLE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIFONAZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:59:48.651821","biosimilars":[],"competitors":[{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"econazole","drugSlug":"econazole","fdaApproval":"1982-12-23","patentExpiry":"Aug 8, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"thiabendazole","drugSlug":"thiabendazole","fdaApproval":"1967-04-07","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tioconazole","drugSlug":"tioconazole","fdaApproval":"1983-02-18","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoconazole","drugSlug":"ketoconazole","fdaApproval":"1981-06-12","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulconazole","drugSlug":"sulconazole","fdaApproval":"1985-08-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxiconazole","drugSlug":"oxiconazole","fdaApproval":"1988-12-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sertaconazole","drugSlug":"sertaconazole","fdaApproval":"2003-12-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"fluconazole","drugSlug":"fluconazole","fdaApproval":"1990-01-29","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"luliconazole","drugSlug":"luliconazole","fdaApproval":"2013-11-14","patentExpiry":"Sep 6, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"efinaconazole","drugSlug":"efinaconazole","fdaApproval":"2014-06-06","patentExpiry":"Oct 24, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"bifonazole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-class"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-class"},{"drugId":"econazole","brandName":"econazole","genericName":"econazole","approvalYear":"1982","relationship":"same-class"},{"drugId":"thiabendazole","brandName":"thiabendazole","genericName":"thiabendazole","approvalYear":"1967","relationship":"same-class"},{"drugId":"tioconazole","brandName":"tioconazole","genericName":"tioconazole","approvalYear":"1983","relationship":"same-class"},{"drugId":"ketoconazole","brandName":"ketoconazole","genericName":"ketoconazole","approvalYear":"1981","relationship":"same-class"},{"drugId":"sulconazole","brandName":"sulconazole","genericName":"sulconazole","approvalYear":"1985","relationship":"same-class"},{"drugId":"oxiconazole","brandName":"oxiconazole","genericName":"oxiconazole","approvalYear":"1988","relationship":"same-class"},{"drugId":"sertaconazole","brandName":"sertaconazole","genericName":"sertaconazole","approvalYear":"2003","relationship":"same-class"},{"drugId":"fluconazole","brandName":"fluconazole","genericName":"fluconazole","approvalYear":"1990","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02705664","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-01","conditions":["Foot Dermatoses"],"enrollment":22,"completionDate":"2016-09"},{"nctId":"NCT01013909","phase":"PHASE2","title":"Comparative Safety and Efficacy Study of New Bifonazol Spray vs Terbinafine Solution vs Placebo","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-12","conditions":["Tinea Pedis"],"enrollment":220,"completionDate":"2010-05"},{"nctId":"NCT00781820","phase":"PHASE3","title":"Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-10","conditions":["Onychomycosis"],"enrollment":693,"completionDate":"2010-01"},{"nctId":"NCT00808366","phase":"NA","title":"Efficacy and Safety of RV4104A Ointment in Onychomycosis","status":"UNKNOWN","sponsor":"Pierre Fabre Dermo Cosmetique","startDate":"2008-10","conditions":["Onychomycosis"],"enrollment":228,"completionDate":"2009-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"004316","UNII":"QYJ305Z91O","CHEBI":"CHEBI:31286","INN_ID":"4887","RXNORM":"19295","UMLSCUI":"C0053570","ChEMBL_ID":"CHEMBL277535","KEGG_DRUG":"D01775","DRUGBANK_ID":"DB04794","PDB_CHEM_ID":" TMI","PUBCHEM_CID":"2378","SNOMEDCT_US":"136216003","MESH_SUPPLEMENTAL_RECORD_UI":"C036596"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":437,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D01AC10","allCodes":["D01AC10","D01AC60"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bifazol is a small molecule inhibitor of the enzyme lanosterol 14-alpha demethylase. It is classified as a drug in the inhibitor class and has synonyms such as BAY H 4502, BAY-H-4502, BIFONAZOL, BIFONAZOLE, and BIFONAZOLE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}