{"id":"bietamiverine","rwe":[],"tags":[{"label":"bietamiverine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Muscarinic acetylcholine receptor M3","category":"target"},{"label":"CHRM3","category":"gene"},{"label":"CHRM1","category":"gene"},{"label":"CHRM2","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"paparid","offLabel":[],"synonyms":["bietamiverine monohydrochloride","bietamiverine hydrochloride","bietamiverine","dietamiverine","novosaprol","paparid","spasmaparid"],"timeline":[],"brandName":"Paparid","ecosystem":[],"mechanism":{"target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","targets":[{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"}],"modality":"Small Molecule","drugClass":"bietamiverine","explanation":"Imagine your body's muscles and glands are like a faucet - when the M3 receptor is turned on, the faucet opens and lets fluid flow. Paparid blocks this receptor, so the faucet stays closed and fluid doesn't flow as much. This can help to reduce symptoms in conditions where the muscles or glands are overactive.","oneSentence":"Paparid works by blocking the M3 receptor, which helps to reduce smooth muscle contraction and glandular secretion.","technicalDetail":"Paparid acts as a competitive antagonist at the M3 muscarinic acetylcholine receptor, inhibiting the binding of acetylcholine and reducing the downstream effects of receptor activation, including smooth muscle contraction and glandular secretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3025","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIETAMIVERINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:03:20.077277","biosimilars":[],"competitors":[{"drugName":"acetylcholine","drugSlug":"acetylcholine","fdaApproval":"1973-10-09","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"aclidinium bromide","drugSlug":"aclidinium-bromide","fdaApproval":"2012-07-23","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atropine","drugSlug":"atropine","fdaApproval":"1960-09-15","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"bietamiverine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylcholine","brandName":"acetylcholine","genericName":"acetylcholine","approvalYear":"1973","relationship":"same-target"},{"drugId":"aclidinium-bromide","brandName":"aclidinium bromide","genericName":"aclidinium bromide","approvalYear":"2012","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atropine","brandName":"atropine","genericName":"atropine","approvalYear":"1960","relationship":"same-target"},{"drugId":"azelastine","brandName":"azelastine","genericName":"azelastine","approvalYear":"1996","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"4MGI916O6Y","CHEBI":"CHEBI:135362","INN_ID":"669","UMLSCUI":"C0602297","ChEMBL_ID":"CHEMBL2110892","PUBCHEM_CID":"72064","SECONDARY_CAS_RN":"1477-10-7","MESH_SUPPLEMENTAL_RECORD_UI":"C005680"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paparid (Bietamiverine) is a small molecule drug that targets the muscarinic acetylcholine receptor M3. It is a member of the bietamiverine drug class, but its commercial status, including whether it is patented or generic, and its approved indications are unknown. The mechanism of action of Paparid involves blocking the M3 receptor, which is involved in smooth muscle contraction and glandular secretion. As a result, Paparid may be used to treat conditions characterized by excessive smooth muscle contraction or glandular secretion. However, its safety and efficacy have not been established through FDA approval.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}