{"id":"bibrocathol","rwe":[{"pmid":"36069049","year":"2022","title":"Triple helix and rod structures of the antiseptic drug bibrocathol revealed by electron crystallography.","finding":"","journal":"Chemical communications (Cambridge, England)","studyType":"Clinical Study"},{"pmid":"22527308","year":"2012","title":"Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %).","finding":"","journal":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","studyType":"Clinical Study"},{"pmid":"17003947","year":"2006","title":"[Bibrocathol eye ointment is efficacious in blepharitis. Results from a randomized, double-blind, controlled clinical trial].","finding":"","journal":"Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft","studyType":"Clinical Study"},{"pmid":"8312825","year":"1993","title":"Antiseptics versus antibiotics in the treatment of the experimental conjunctivitis caused by Staphylococcus aureus.","finding":"","journal":"German journal of ophthalmology","studyType":"Clinical Study"}],"tags":[{"label":"bibrocathol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"S01AX05","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T15:53:01.266841","allNames":"bibrocathin","offLabel":[],"synonyms":["bibrocathol","bibrocathin","bismucatebrol"],"timeline":[],"brandName":"Bibrocathin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bibrocathol","explanation":"Imagine your body's cells have a specific lock on the door, and bibrocathol is a key that fits into that lock. When it binds to the lock, it prevents other molecules from entering or leaving the cell, which can affect how the cell functions. This can be useful in treating certain diseases, but it's a complex process that requires more research to fully understand.","oneSentence":"Bibrocathol is thought to work by inhibiting a specific enzyme or receptor, although the exact details of its mechanism are not well understood.","technicalDetail":"Bibrocathol is a bibrocathol class compound that likely acts as a competitive inhibitor of a specific enzyme or receptor, although the precise molecular target and binding mechanism remain unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4352","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BIBROCATHOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BIBROCATHOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:03:15.963899","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:40.055092+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"nitrofurazone","drugSlug":"nitrofurazone","fdaApproval":"1945-10-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"resorcinol","drugSlug":"resorcinol","fdaApproval":"","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"povidone-iodine","drugSlug":"povidone-iodine","fdaApproval":"1985-11-29","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"bibrocathol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(4)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nitrofurazone","brandName":"nitrofurazone","genericName":"nitrofurazone","approvalYear":"1945","relationship":"same-class"},{"drugId":"resorcinol","brandName":"resorcinol","genericName":"resorcinol","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"},{"drugId":"povidone-iodine","brandName":"povidone-iodine","genericName":"povidone-iodine","approvalYear":"1985","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01357538","phase":"PHASE4","title":"Efficacy and Safety of Posiformin 2 % Eye Ointment in the Treatment of Blepharitis","status":"COMPLETED","sponsor":"Ursapharm Arzneimittel GmbH","startDate":"2009-02","conditions":["Blepharitis","Signs and Symptoms"],"enrollment":197,"completionDate":"2009-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006837","UNII":"0KJ20H1BLJ","CHEBI":"CHEBI:135953","INN_ID":"79","UMLSCUI":"C0602838","ChEMBL_ID":"CHEMBL44875","KEGG_DRUG":"D07414","DRUGBANK_ID":"DB13818","PUBCHEM_CID":"16683103","MESH_SUPPLEMENTAL_RECORD_UI":"C006748"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"S01AX05","allCodes":["S01AX05"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bibrocathol is a small molecule drug in the bibrocathol class, developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. Bibrocathol is not FDA-approved for any indications, and its commercial status, half-life, bioavailability, generic manufacturers, and patent status are unknown. As a result, there is limited information available on its safety profile and clinical use. Further research is needed to determine the potential therapeutic applications and risks associated with bibrocathol.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:40.055092+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}