{"id":"betazole","rwe":[{"pmid":"38783010","year":"2024","title":"Comparing ANI-2x, ANI-1ccx neural networks, force field, and DFT methods for predicting conformational potential energy of organic molecules.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"37215570","year":"2023","title":"Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice.","finding":"","journal":"Theranostics","studyType":"Clinical Study"},{"pmid":"34220333","year":"2021","title":"Biocatalytic access to betazole using a one-pot multienzymatic system in continuous flow.","finding":"","journal":"Green chemistry : an international journal and green chemistry resource : GC","studyType":"Clinical Study"},{"pmid":"32120072","year":"2020","title":"Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.","finding":"","journal":"Bioorganic chemistry","studyType":"Clinical Study"},{"pmid":"29329257","year":"2018","title":"Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"}],"tags":[{"label":"betazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H2 receptor","category":"target"},{"label":"HRH2","category":"gene"},{"label":"V04CG02","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Stimulated gastric secretory test","category":"indication"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=BETAZOLE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:51:33.503302+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Betazole","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-19T23:51:40.734851+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:51:39.323560+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BETAZOLE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:51:39.676579+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201323/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:51:40.377170+00:00"}},"allNames":"histalog","offLabel":[],"synonyms":["betazole hydrochloride","betazole","betazole HCl","histalog","betazole dihydrochloride","ametazole"],"timeline":[],"aiSummary":"Histalog (BETAZOLE) is a small molecule betazole drug that targets the histamine H2 receptor. It is used for the stimulated gastric secretory test, but its commercial status is off-patent with no active Orange Book patents. Histalog works by blocking the histamine H2 receptor, which reduces gastric acid secretion. As an off-patent drug, it is not commercially available from generic manufacturers. Key safety considerations are not well-documented due to the lack of FDA approval and available information.","brandName":"Histalog","ecosystem":[{"indication":"Stimulated gastric secretory test","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Histamine H2 receptor","novelty":"First-in-class","targets":[{"gene":"HRH2","source":"DrugCentral","target":"Histamine H2 receptor","protein":"Histamine H2 receptor"}],"modality":"Small Molecule","drugClass":"betazole","explanation":"","oneSentence":"","technicalDetail":"Histalog is a competitive antagonist of the histamine H2 receptor, which is a G-protein coupled receptor that stimulates gastric acid secretion when activated by histamine."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Betazole","title":"Betazole","extract":"Betazole (also known as ametazole) is a histamine H2 receptor agonist. Betazole hydrochloride is known as gastramine and histalog."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/357","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BETAZOLE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Betazole","fields":["history","overview"],"source":"Wikipedia"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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