{"id":"betaxolol-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Tearing"},{"rate":null,"effect":"Systemic beta-blocker effects (rare with topical use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Betaxolol selectively blocks beta-1 adrenergic receptors on the ciliary body epithelium, which reduces the production and secretion of aqueous humor. This leads to a decrease in intraocular pressure, making it effective for treating glaucoma and ocular hypertension. As an eye drop formulation, it provides local ocular effects with minimal systemic absorption.","oneSentence":"Betaxolol is a selective beta-1 adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:07.057Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT02617459","phase":"PHASE3","title":"Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.","startDate":"2019-01-04","conditions":"Primary Open-angle Glaucoma, Ocular Hypertension","enrollment":366}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"SEDATION"},{"count":1,"reaction":"ABNORMAL LOSS OF WEIGHT"},{"count":1,"reaction":"AGITATION"},{"count":1,"reaction":"ANAEMIA"},{"count":1,"reaction":"CONTRAINDICATED PRODUCT ADMINISTERED"},{"count":1,"reaction":"CONTUSION"},{"count":1,"reaction":"DECREASED APPETITE"},{"count":1,"reaction":"DELIRIUM"},{"count":1,"reaction":"FALL"},{"count":1,"reaction":"MYOCARDIAL INFARCTION"}],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Betaxolol eye drops","genericName":"Betaxolol eye drops","companyName":"Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.","companyId":"zhaoke-guangzhou-ophthalmology-pharmaceutical-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Betaxolol is a selective beta-1 adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}